Design and synthesis of quinazolinone derivatives as anti-inflammatory agents: Pharmacophore modeling and 3D QSAR studies
A series of 36 novel substituted quinazolinone derivatives were synthesized and evaluated for their antiinflammatory activity by carrageenan induced paw inflammation model. The ability of these compounds to inhibit cyclooxygenase (COX-1 and 2) enzyme has
Chaitanya,Reddy, G. Deepak,Varun,Srikanth,Prasad,Ravindernath
p. 711 - 723
(2015/04/14)
Plasminogen Activator Inhibitor-1 Inhibitor
The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity.
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Page/Page column 67
(2012/02/03)
The Vilsmeier cyclisation of azides: A novel route towards the synthesis of imidazo[1,2-a]quinazoline-1,5-diones
Imidazo[1,2-a]quinazoline-1,5-diones 2a-d have been prepared in one pot from 2-azido-N-(2-carboxyaryl)acetamides 1a-d.
Akila,Majo,Balasubramanian
p. 647 - 649
(2007/10/03)
Substituted (2-oxo-1-benzimidazolinyl)-peperidines, process for their preparation, and use as anti-retroviral agents
The present invention relates to substituted (2-oxo-1-benzimidazolinyl)-piperidines of the general formula (I) STR1 in which the substituents have the meaning indicated in the description, to processes for their preparation and to their use as antiretrovi
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(2008/06/13)
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