- Preparation method of sulfydryl alkenyl ester compound
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The invention relates to a preparation method of a sulfydryl alkenyl ester compound, belongs to the field of organic chemical synthesis, and aims to solve the problems of high risk of large-scale production and the like, and the synthesis route provided b
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Paragraph 0041-0044
(2021/07/21)
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- Enantioselective Lactonization by π-Acid-Catalyzed Allylic Substitution: A Complement to π-Allylmetal Chemistry
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Asymmetric allylic alkylation (AAA) is a powerful method for the formation of highly useful, non-racemic allylic compounds. Here we present a complementary enantioselective process that generates allylic lactones via π-acid catalysis. More specifically, a
- Kizhakkayil Mangadan, Arun Raj,Liu, Ji,Aponick, Aaron
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supporting information
p. 22224 - 22229
(2021/09/09)
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- CYLCOALKENYL DERIVATIVES USEFUL AS AGONISTS OF THE GPR120 AND /OR GPR40 RECEPTORS
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The present invention is directed to cycloalkenyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the GPR120 and / or GPR40 receptors. 5 More particularly, the compounds of the present invention are agonists of GPR120 and / or GPR40, useful in the treatment of, for example, obesity, Type II Diabetes Mellitus, dyslipidemia, etc.
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Page/Page column 94-95
(2019/10/01)
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- Pd-Catalyzed Difluoromethylation of Vinyl Bromides, Triflates, Tosylates, and Nonaflates
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Pd-catalyzed difluoromethylation of di-, tri- or tetra-substituted vinyl bromides, triflates, tosylates and nonaflates under mild conditions is described. The reaction tolerates a wide range of functional groups, such as bromide, chloride, fluoride, ester, amine, nitrile, and protected carbonyl, thus providing a general route for the preparation of difluoromethylated alkenes. Vinyl fantasy: Pd-catalyzed difluoromethylation of di-, tri-, or tetra-substituted vinyl bromides, triflates, tosylates, and nonaflates under mild conditions is described. The reaction tolerates a wide range of functional groups, such as bromide, chloride, fluoride, ester, amine, nitrile, and protected carbonyl, thus providing a general route for the preparation of difluoromethylated alkenes.
- Chang, Dalu,Gu, Yang,Shen, Qilong
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supporting information
p. 6074 - 6078
(2015/04/14)
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- Catalytic enantioselective nazarov cyclization: Construction of vicinal all-carbon-atom quaternary stereocenters
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The diastereoselective asymmetric synthesis of vicinal all-carbon-atom quaternary stereocenters is a challenging problem in organic synthesis for which only few solutions have been described. A catalytic asymmetric Nazarov cyclization of fully substituted dienones that provides cyclopentenone derivatives with vicinal quaternary stereocenters in high optical purity and as single diastereoisomers is now reported.
- Jolit, Anais,Walleser, Patrick M.,Yap, Glenn P. A.,Tius, Marcus A.
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supporting information
p. 6180 - 6183
(2014/06/23)
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- A convenient method for the synthesis of Δ1,6-bicyclo[4.n.0]alken-2-ones
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A convenient annulation method for the synthesis of bicyclic enones from cycloalkanones was developed. In the presence of a Pd(0) catalyst, enol triflates derived from ethyl 2-oxocycloalkanecarboxylates were treated with 3-(ethoxycarbonyl)propylzinc iodid
- Watanabe, Norihiko,Tanino, Keiji,Kuwajima, Isao
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p. 8133 - 8136
(2007/10/03)
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- Restricted 9-cis retinoids
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The invention is novel analogs of 9-cis-retinoic acid which are useful for the treatment and prevention of coronary artery disease and to protect against premature atherosclerosis by increasing HDL levels. The invention includes processes for preparing th
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