- Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors
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A series of 4-azaindole-containing p21-activated kinase-1 (PAK1) inhibitors was prepared with the goal of improving physicochemical properties relative to an indole starting point. Indole 1 represented an attractive, non-basic scaffold with good PAK1 affinity and cellular potency but was compromised by high lipophilicity (c log D = 4.4). Azaindole 5 was designed as an indole surrogate with the goal of lowering log D and resulted in equipotent PAK1 inhibition with a 2-fold improvement in cellular potency over 1. Structure–activity relationship studies around 5 identified additional 4-azaindole analogs with superior PAK1 biochemical activity (Kia 20-fold decrease in unbound clearance in mouse PK studies for azaindole 5 relative to indole 1.
- Lee, Wendy,Crawford, James J.,Aliagas, Ignacio,Murray, Lesley J.,Tay, Suzanne,Wang, Weiru,Heise, Christopher E.,Hoeflich, Klaus P.,La, Hank,Mathieu, Simon,Mintzer, Robert,Ramaswamy, Sreemathy,Rouge, Lionel,Rudolph, Joachim
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p. 3518 - 3524
(2016/07/21)
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- 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS
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Compounds having the formula I wherein A, Rla, Rlb, R2, R3, R4, R5, R6, R7, Rs, Ra, Rb, X1, X2, X3 and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders
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