Metal-free synthesis of secondary arylamines: An aliphatic-to-aromatic transformation
An efficient method for the N-arylation of primary and some secondary amines using 2-halocyclohex-2-enones in an aliphatic-to-aromatic transformation in the presence of a substoichiometric amount of pTsOH has been developed. A series of arylamines have been synthesized from 2-halocyclohex-2-enones by in situ enamine formation followed by aromatization under environmentally friendly conditions using pTsOH. This metal-free, practical, relatively inexpensive protocol is of value in organic synthesis for industrial and academic applications. Copyright
Barros, M. Teresa,Dey, Suvendu S.,Maycock, Christopher D.
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p. 742 - 747
(2013/03/13)
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