- New addition salt of N-amino-N'-pentylguanidine, the process for its preparation and use thereof for obtaining tegaserod
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The present invention refers to a new addition salt of N-amino-N'-pentylguanidine, particularly to the oxalate addition salt of N-amino-N'-pentylguanidine. The process for preparing said oxalate addition salt comprises the steps of: a) reacting the N-amino-N'-pentylguanidine, as a free base or in a salt form, with oxalic acid in a polar medium; and b) recovering the product in a solid form. This addition salt is useful for obtaining the tegaserod free base with a better purity and yield.
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Page/Page column 3
(2008/12/07)
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- STABLE MODIFICATIONS OF TEGASEROD HYDROGEN MALEATE
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The present invention relates to crystalline forms of tegaserod hydrogen maleate, their use, in pharmaceutical compositions useful in the treatment of irritable bowel syndrome, gastro-esophageal reflux disease, functional dyspepsia, chronic constipation or diarrhea, and their production.
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Page/Page column 10-11
(2010/02/10)
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