cas 145238-45-5, (R)-Tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, 99% (R)-Phenyl oxazaborolidine

A method of preparing a compound of Formula (I) comprising reacting the compound of Formula (A) with a base and a compound of Formula (B) to yield a compound of Formula (C).

Streptogramin antibiotics are used clinically to treat multidrug-resistant bacterial infections, but their poor physicochemical properties and narrow spectra of activity have limited their utility. New methods to chemically modify streptogramins would enable structural optimization to overcome these limitations as well as to combat growing resistance to the class. Here we report a modular, scalable synthesis of group A streptogramin antibiotics that proceeds in 6-8 linear steps from simple chemical building blocks. We have applied our route to the synthesis of four natural products in this class including two that have never before been accessed by fully synthetic routes. We anticipate that this work will lead to the discovery of new streptogramin antibiotics that overcome previous limitations of the class.

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145238-45-5

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Chemical Properties

Boiling Point: 457.775 °C at 760 mmHg

Flash Point:230.654 °C

Density: 1.172 g/cm³

PKA: -0.33±0.40(Predicted)

Sensitive: moisture sensitive

PSA: 12.47000

LogP: 3.75810

Global suppliers and manufacturers of 145238-45-5total 26 suppliers on LookChem

Article Database

145238-45-5

Articles about 145238-45-5Total 2 be found

More Articles about upstream products of 145238-45-5

Chemical Properties

Boiling Point: 457.775 °C at 760 mmHg

Flash Point:230.654 °C

Density: 1.172 g/cm3

PKA: -0.33±0.40(Predicted)

Sensitive: moisture sensitive

PSA: 12.47000

LogP: 3.75810

Global suppliers and manufacturers of 145238-45-5total 26 suppliers on LookChem

Density: 1.172 g/cm³