Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists
Dihydrofuran-2-one and dihydropyrrol-2-one derivatives were identified as novel, potent and selective mineralocorticoid receptor (MR) antagonists by the structure-based drug design approach utilizing the crystal structure of MR/compound complex. Introduct
Hasui, Tomoaki,Ohra, Taiichi,Ohyabu, Norio,Asano, Kouhei,Matsui, Hideki,Mizukami, Atsushi,Habuka, Noriyuki,Sogabe, Satoshi,Endo, Satoshi,Siedem, Christopher S.,Tang, Tony P.,Gauthier, Cassandra,De Meese, Lisa A.,Boyd, Steven A.,Fukumoto, Shoji
p. 5983 - 5994
(2013/09/23)
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