G protein coupled receptor agonist and application thereof in treatment of diabetes
The invention discloses a structure of a compound. The structural formula of the compound is shown in the description. Found by activity determination, the structure has the effect of a G protein coupled receptor 119 agonist; the G protein coupled receptor 119 agonist has the functions of not causing hypoglycemia of patients and promoting GLP-1 secretion. The compound disclosed by the invention can be further researched and developed as a diabetes-resisting drug. Besides, the invention further discloses a synthesis route and a synthesis method for the compound.
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Paragraph 0017; 0018
(2018/06/16)
SPIRO-CONDENSED PYRROLIDINE DERIVATIVES AS DEUBIQUITYLATING ENZYMES (DUB) INHIBITORS
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1. The invention further relates to the use of DUB inhibitors in the treatment of cancer. (Figure (I))
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Page/Page column 45-47
(2017/09/15)
INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE
This invention discloses amino acid derivatives which display inhibitory effects on the serine protease factor Xa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, methods for the preparation of the compounds, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
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Page 86-87
(2010/02/06)
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