Preparation of 2,3-Disubstituted 5-Bromo-1 H -pyrrolo[2,3- b ]pyridine Framework by Fischer Cyclization
A simple synthesis of some hard-to-reach heterocycles containing 2,3-disubstituted 5-bromo-1H-pyrrolo[2,3-b]pyridine framework by FisNher indole cyclization in polyphosphoric acid has been developed. A particularly valuable feature of this synthetic route is the possibility to build a 5-bromo-7-azaindole scaffold with alkyl or aryl substituents at positions 2 and 3 from available starting materials.
Alekseyev, Roman S.,Amirova, Sabina R.,Terenin, Vladimir I.
p. 3169 - 3178
(2015/10/19)
IMIDAZOPYRIDIN-2-ONE DERIVATIVES
A compound represented by formula (I) having mTOR inhibitory activity or a pharmacologically acceptable salt thereof.
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Page/Page column 66
(2011/04/24)
PYRAZOLE COMPOUNDS
The present invention is directed to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
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Page/Page column 70-71
(2009/03/07)
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