Characterisation of antibody models of the ryanodine receptor for use in high-throughput screening
The syntheses of seven novel synthetic analogues of the naturally occurring insecticide ryanodine are described. These, and other synthetic and naturally occurring analogues, have been used to characterise the selectivity of a monoclonal antibody which ha
C10-O(eq)-N-(4-azido-5-125iodo salicyloyl)-β-alanyl-β-alanyl ryanodine (Az-βAR), a novel photo-affinity ligand for the ryanodine binding site
A high affinity, photoactivatable, radio-iodinated ligand for the ryanodine binding site(s) of the sarcoplasmic reticulum calcium-release channel, C10-O(e)-N-(4-azido-5-125iodo salicyloyl)-β-alanyl-β-alanyl ryanodine (Az-βAR), was sy
Amino- and Guanidinoacylryanodines: Basic Ryanodine Esters with Enhanced Affinity for the Sarcoplasmic Reticulum Ca2+-Release Channel
Amino- and guanidinoacyl esters of ryanodine were prepared to evaluate the effect of basicity on the binding affinity of these derivatives for the sarcoplasmic reticulum Ca2+-release channel (SR CRC). In the presence of DCC and DMAP Cbz-β-alani
Gerzon, Koert,Humerickhouse, Rod A.,Besch, Henry R.,Bidasee, Keshore R.,Emmick, Jeffrey T.,et al.
p. 1319 - 1323
(2007/10/02)
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