- Convergent synthesis of tetra- and penta-saccharide fragments of dimeric Lewis X
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The convergent synthesis of tetra- and penta-saccharide fragments of the TACA dimeric Lex is described. The synthetic strategy relied on the preparation of a protected GlcNTCA-(1,3)-Gal-(1,4)-GlcNAc trisaccharide diol free at O-3 of both glucos
- Forman, Adam,Hendel, Jenifer,Auzanneau, France-Isabelle
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- N-ACETYLGLUCOSAMINE DERIVATIVES AND USE THEREOF
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The present invention relates to An N-acetylglucosamine derivative represented by the following formula (1), and a hyaluronic acid production promoting agent containing the same and a skin external preparation containing the same: wherein R1 is a hydrogen atom or an alkyl group having 2 to 18 carbon atoms; R2, R3, and R4 are hydrogen atoms or acyl groups having 2 to 18 carbon atoms and may be all the same or different from others; the steric structure at position 1 may be α or β; provided that R1, R2, R3, and R4 must not be all hydrogen atoms. It is intended to provide an easily available hyaluronic acid production promoting agent and a skin external preparation whereby the production of hyaluronic acid can be promoted in the skin and thus the skin can be maintained in a vital and moist state so that it is expected that the human skin can be prevented from age.
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Page/Page column 14-15
(2010/02/12)
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- Use of sodium iodide and crown ether in the synthesis of N-acetylglucosamine glycosides
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A pair of sodium iodide-crown ether reagents was used in the synthesis of N-acetylglucosamine glycosides. At room temperature, the reaction resulted in β-glycosides, whereas at 85-90°C, it gave a mixture of anomers or α-anomer only.
- Kur'yanov,Zemlyakov,Chupakhina,Chirva
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p. 282 - 283
(2007/10/03)
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- Process for the specific synthesis of β-glycosidically linked N-acetylpyranoside derivatives
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A process for the stereospecific synthesis of β-glycosidically linked N-acetylglucosamine derivatives is provided, wherein a protected α-(N-acetyl-2-amino-2-deoxy)-β-pyranosyl halide is coupled to a glycosyl acceptor using zinc chloride and a 4,4'-dialkox
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- A spacer-modified disaccharide as a photoaffinity reagent for the acceptor-binding area of bovine (1->4)-β-D-galactosyltransferase: comparison of its acceptor properties with those of other 2-acetamido-2-deoxy-β-D-glucopyranosides
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The spacer-modified disaccharide 1,10-di-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-azi-1,10-decanediol (10) that mimics the biantennary core heptasaccharide of N-glycoproteins has been synthesised.Compound 10 is an excellent acceptor in galactosyltransferase-catalysed galactosylation by UDP-galactose, is superior (7-8 fold) to analogues that have only one GlcNAc unit, and is an efficient photoaffinity reagent for galactosyltransferase.In the presence of UDP-Gal, no photoaffinity labelling by 10 takes place, which agrees with the mechanism of galactosyltransferase action.
- Ats, Sandor-Csaba,Lehmann, Jochen,Petry, Stefan
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p. 125 - 139
(2007/10/02)
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