- Indium-mediated tandem dimerization and cyclization of nitrqones and aldimines to 3-arylaminodihydrobenzofurans under aqueous conditions
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Nitrones undergo deoxygenative reductive coupling and subsequent cyclization to 3-arylamino-2,3-dihydrobenzofuran derivatives in the presence of indium under aqueous conditions at ambient temperature in good yields.
- Jeevanandam, Arumugasamy,Ling, Yong-Chien
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- Synthesis, characterization and anti-cancer studies of Mn(II), Cu(II), Zn(II) and Pt(II) dithiocarbamate complexes - crystal structures of the Cu(II) and Pt(II) complexes
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Mn(II), Cu(II), Zn(II) and Pt(II) complexes of 2-((p-tolylamino)methyl)phenolyldithiocarbamate were synthesized and characterized by elemental analyses and spectroscopic techniques. Spectroscopic studies indicate four coordinate geometry around the metal(
- Ajibade, Peter A.,Fatokun, Amos A.,Andrew, Fartisincha P.
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- Screening of simple carbohydrates as a renewable organocatalyst for the efficient construction of 1,3-benzoxazine scaffold
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A convenient protocol for the two component preparation of 1,3-benzoxazines by using several protected and unprotected carbohydrate molecules as organocatalysts have been developed which is broadly applicable to condensation reaction between variety of Ma
- Y?ld?r?m, Ayhan,Kaya, Yunus,G?ker, Mustafa
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- Metal-Free Diaryl Etherification of Tertiary Amines by Ortho-C(sp2)-H Functionalization for Synthesis of Dibenzoxazepines and -ones
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A phenyliodine(III) diacetate mediated umpolung reactivity of the tertiary amines with suitably substituted o-hydroxybenzyl and phenyl groups is exploited to facilitate o-C(sp2)-H functionalization to afford diaryl ethers. The presence of an o-
- Jamsheena, Vellekkatt,Mahesha, Chikkagundagal K.,Joy, M. Nibin,Lankalapalli, Ravi S.
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supporting information
p. 6614 - 6617
(2017/12/26)
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- Influence of substituent on equilibrium of benzoxazine synthesis from Mannich base and formaldehyde
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N-Substituted aminomethylphenol (Mannich base) and 3,4-dihydro-2H-3- substituted 1,3-benzoxazine (benzoxazine) were synthesized from substituted phenol (p-cresol, phenol, p-chlorophenol), substituted aniline (p-toluidine, aniline, p-chloroaniline) and formaldehyde to study influence of substituent on equilibrium of benzoxazine synthesis from Mannich base and formaldehyde. 1H-NMR and charges of nitrogen and oxygen atoms illustrate effect of substituent on reactivity of Mannich base, while oxazine ring stability is characterized by differential scanning calorimetry (DSC) and C-O bond order. Equilibrium constants were tested from 50 °C to 80 °C, and the results show that substituent attached to phenol or aniline has same impact on reactivity of Mannich base; however, it has opposite influence on oxazine ring stability and equilibrium constant. Compared with the phenol-aniline system, electron-donating methyl on phenol or aniline increases the charge of nitrogen and oxygen atoms in Mannich base. When the methyl group is located at para position of phenol, oxazine ring stability increases, and the equilibrium constant climbs, whereas when the methyl group is located at the para position of aniline, oxazine ring stability decreases, the benzoxazine hydrolysis tends to happen and equilibrium constant is significantly low. the Partner Organisations 2014.
- Deng, Yuyuan,Zhang, Qin,Zhou, Qianhao,Zhang, Chengxi,Zhu, Rongqi,Gu, Yi
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p. 18341 - 18348
(2014/09/30)
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- Synthesis of 3-(4-Methyl-phenyl)-2-phenyl-3,4-dihydro-2H-benzo[e][1,3,2] oxazaphosphinine and Its Chalcogenides
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A simple method for the synthesis of 3-(4-methyl-phenyl)-2-phenyl-3,4- dihydro-2H-benzo[e][1,3,2]oxazaphosphinine (2) is described. P-Chalcogenides of (2) can be prepared by reacting with S, Se powder in toluene at 110°C. Whereas the tungsten pentacarbony
- Rani, Manju,Shukla, Davender Kumar,Khan, Arif Ali
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p. 3449 - 3451
(2013/05/09)
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- A quick route for the synthesis of 3-Aryl-3,4-dihydro-2H-benz[e]-1,3- oxazin-2-ones
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N-(2-Hydroxy)-benzyl-arylamines (1) gave substantially pure 3-aryl-3,4-dihydro-2H-benz[e]-1,3-oxazin-2-one 2 on cyclization with carbonyldiimidazole in DMSO in 20-30 min at 20-25 °C in excellent yields.
- Shukla, Davender Kumar,Rani, Manju,Khan, Arif Ali
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p. 4537 - 4540
(2013/06/27)
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- Efficient synthesis of 2,3-disubstituted-1,3-benzoxazines by chlorotrimethylsilane-mediated aza-acetalizations of aromatic aldehydes
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A series of novel substituted 3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to good yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of chlorotrimethylsilane or SnCl4. It w
- Tang, Zilong,Zhu, Zhonghua,Yan, Lin,Chang, Shuhong,Liu, Hanwen
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p. 1116 - 1120
(2013/10/21)
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- Synthesis and biological activity of some 3-aryl-3,4-dihydro-2h-benz[e]-1, 3-oxazines/6-bromo-3-aryl-3,4-dihydro-2h-benz[e]-1,3-oxazines
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N-(2-Hydroxy)-benzyl-arylamine (1) gives substantially pure 3-aryl-3,4-dihydro-2H-benz[e]-1,3-oxazines/6-bromo-3-aryl-3,4-dihydro-2H-benz[e] -1,3-oxazines (2) on cyclization with formaldehyde in methanol within 0.5-1.0 h at 65-68 C in excellent yields. Th
- Shukla, Davender Kumar,Rani, Manju,Khan, Arif Ali,Tiwari, Kavita,Gupta, Rajinder K.
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p. 5921 - 5924
(2013/07/26)
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- SnCl4-catalyzed aza-acetalization of aromatic aldehydes: Synthesis of aryl substituted 3,4-dihydro-2H-1,3-benzoxazines
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Stannic tetrachloride was an efficient Lewis acid catalyst for the aza-acetalization of aromatic aldehydes with o-arylaminomethyl phenols, and a series of novel aryl substituted 3,4-dihydro-2H-1,3-benzoxazines were prepared in good yields under mild condi
- Tang, Zilong,Chen, Weiwen,Zhu, Zhonghua,Liu, Hanwen
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scheme or table
p. 1372 - 1383
(2012/04/04)
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- Synthesis and fungicidal activity of novel 2,3-disubstituted-1,3- benzoxazines
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A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed
- Tang, Zilong,Zhu, Zhonghua,Xia, Zanwen,Liu, Hanwen,Chen, Jinwen,Xiao, Wenjing,Ou, Xiaoming
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scheme or table
p. 8174 - 8185
(2012/09/25)
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- Synthesis of 2,3-diaryl-3,4-dihydro-2H-1,3-benzoxazines and their fungicidal activities
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A series of novel 2,3-diaryl-3,4-dihydro-2H-1,3-benzoxazines have been prepared in high yields from o-arylaminomethylphenols and aromatic aldehydes in the presence of SnCl4 for the first time, and their fungicidal activities were investigated t
- Tang, Zilong,Chen, Weiwen,Zhu, Zhonghua,Liu, Hanwen
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p. 255 - 260
(2011/06/19)
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- Synthesis and structure-antibacterial activity relationship studies of 4-substituted phenyl-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-thiones
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The synthesis and characterization of a series of 4-substituted phenyl-4,5-dihydrobenzo[f][1,4]oxazepin- 3(2H)-thiones were presented. Preliminary in vitro antimicrobial activity of the compounds was assessed against a panel of microorganisms including S.
- Agirbas, Hikmet,Kemal, Berat,Budak, Fatma
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experimental part
p. 1170 - 1180
(2012/05/05)
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- Monocyclopentadienyl phenoxido-amino and phenoxido-amido titanium complexes: Synthesis, characterisation, and reactivity of asymmetric metal centre derivatives
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Reduction of phenol-imine derivatives R′N=CH(3,5-R2C 6H2-2-OH) (R = tBu; R′ = C6H5 1a, p-MeC6H4 1b, Cy 1c, tBu 1d, 2,6-Me2C 6H3 1e; R = H; R′ = p
- Alesso, Giuseppe,Sanz, Martial,Mosquera, Marta E. G.,Cuenca, Tomas
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experimental part
p. 4638 - 4649
(2009/03/12)
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- Reductive amination of aldehydes and ketones with sodium borohydride supported onto HZSM-5 zeolite under microwave irradiation in a solvent free system
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Sodium borohydride supported onto a HZSM-5 zeolite is presented as a general reducing agent for the reductive amination of aldehydes and ketones under microwave irradiation in solventless system. Copyright Taylor & Francis Inc.
- Oskooie, Hossein A.,Amiri, Somaih Solemani,Heravi, Majid M.,Ghassemzadeh, Mitra
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p. 2047 - 2050
(2007/10/03)
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- Qualitative analysis of the stability of the oxazine ring of various benzoxazine and pyridooxazine derivatives with proton nuclear magnetic resonance spectroscopy
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A series of 3,4-dihydro-1,3-benzoxazine and 3,4-dihydro-1,3-pyridooxazine derivatives was synthesized, and the hydrolysis of the derivatives was studied with proton nuclear magnetic resonance spectroscopy. The oxazine derivatives underwent various degrees of hydrolysis when H2O was added to dimethyl sulfoxide solutions of the compounds. The rates and extents of decomposition of the oxazine ring systems depended on the electronic effects of substituents within the molecules. Examination of the proton nuclear magnetic resonance spectra that were generated during decomposition of the oxazines and trends in stability of the oxazine derivatives suggest the formation of an intermediate in the hydrolysis mechanism.
- Moloney,Craik,Iskander
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p. 692 - 697
(2007/10/02)
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- The Condensation of Cyclic Anhydrides with Schiff Bases. A Convenient Synthesis of 1,4,6-Triaryl-5-carboxy-2-oxo-1,2-dihydropyridines and 2,3-Diaryl-4-carboxy-1-oxo-1,2-dihydroisoquinolines
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Condensation of Schiff bases of o-hydroxyarenecarboxaldehydes with 3-arylpentenedioic or homophthalic acid anhydrides was found to give 1,4,6-triaryl-5-carboxy-2-oxo-1,2-dihydropyridines and 2,3-diaryl-4-carboxy-1-oxo-1,2-dihydroisoquinolines, respectivel
- Mayadeo, M. S.,Kulkarni, S. J.,Deodhar, K. D.
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- New Route for the Preparation of 2H-3-Aryl-3,4-dihydro-1,3-benzoxazines and 2H-3-Aryl-3,4-dihydro-4-methyl-1,3-benzoxazines
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2-Hydroxybenzaldehyde (1) and 1-(2-hydroxyphenyl)ethanone (2) on reaction with different primary aromatic amines gave 2-(arylimino)methylphenols (3) and 2-phenols (4), respectively. 3 and 4 on reduction with sodium borohydride gave 2-(arylamino)methylphenols (5) and 2-phenols (6), which underwent cyclisation with formaldehyde to form 2H-3-aryl-3,4-dihydro-1,3-benzoxazines (7) and 2H-3-aryl-3,4-dihydro-4-methyl-1,3-benzoxazines (8), respectively.
- Joglekar, S. J.,Samant, S. D.
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p. 110 - 111
(2007/10/02)
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- THERMAL DECOMPOSITION OF 2-HYDROXYBENZYLAMINES
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The results are given of the preparation of a number of 2-hydroxybenzylamines and their thermal decomposition.The thermolysis reactions and the formation of the corresponding amines take place smoothly and with good yields.
- Vinogradova, V. I.,Yunusov, M. S.
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p. 308 - 311
(2007/10/02)
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