- An efficient palladium catalyzed stereocontrolled synthesis of 4a-angular methyl substituted hydrofluorenes
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A high yield stereoselective synthesis of 4a-angularly methyl substituted cis-hexahydrofluorenes 5a-h and tetrahydrofluorenes 7a,b has been developed by palladium-catalyzed intramolecular Heck-type cyclization of the respective exo-olefins 4a-h and 4a,b t
- Mukhopadhyaya,Pal,Ghatak
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- Synthesis and Pharmacological Evaluation of Hexahydrofluorenamines as Noncompetitive Antagonists at the N-Methyl-D-aspartate Receptor
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The noncompetitive (PCP) site of the N-methyl-D-aspartate (NMDA) receptor complex has been implicated in a number of pathologies, including the etiology of ischemic stroke.Recent testing has shown that cis-1,2,3,4,9,9a-hexahydro-N-methyl-4aH-fluoren-4a-am
- Hays, Sheryl J.,Novak, Perry M.,Ortwine, Daniel F.,Bigge, Christopher F.,Colbry, Norman L.,et al.
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p. 654 - 670
(2007/10/02)
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