- Chemo-enzymatic synthesis of oligosaccharides using a dendritic soluble support
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A new soluble support with high loading capacity is described. This support was used for chemical sulfatation and enzymatic synthesis of the trisaccharide Lewis(x). (C) 2000 Elsevier Science Ltd.
- Lubineau,Malleron,Le Narvor
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- Preparation method of pentaerythritol triallyl ether
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The invention provides a pentaerythritol triallyl ether preparation method, and the method comprises: S1, adding pentaerythritol monoallyl ether and sodium hydroxide into a reaction kettle, heating, carrying out a degassing and dehydration reaction for 3-7 h, slowly adding allyl chloride into the reaction kettle, and carrying out a thermal insulation reaction for 3-6 h; S2, performing cooling to below 35 DEG C, adding water into sodium chloride with the same amount of substance as sodium hydroxide in S1 to prepare a sodium chloride saturated solution, standing for layering, discharging a lower-layer aqueous solution, and reserving an upper-layer semi-finished product pentaerythritol diallyl ether; S3, adding sodium hydroxide into the semi-finished product, and repeating the steps S1 and S2to obtain a pentaerythritol triallyl ether crude product. According to the process, a phase transfer catalyst is not needed, so that the cost is saved; compared with the existing process, the feedingof sodium hydroxide and allyl chloride is greatly reduced, and one hydroxyl group is averagely excessive by 2.5% in the reaction; feeding is reduced, by-products are reduced, rectification is not needed, direct post-treatment can be achieved, and cost is further saved.
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Paragraph 0015; 0024-0032
(2021/03/13)
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- Synthetic method of pentaerythritol triallyl ether
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The invention relates to a synthesis method of pentaerythritol triallyl ether, wherein the synthesis method comprises the following steps: reacting pentaerythritol with chloropropene in a hydroxide aqueous solution to generate pentaerythritol triallyl ether, and adding 2-15 wt% of an allyl alcohol accelerator into every 100 parts by weight of pentaerythritol; and after the reaction is finished, separating a reaction product to obtain a product containing pentaerythritol triallyl ether. According to the synthesis method, the allyl alcohol compound is added as a reaction promoter to promote the reaction, the reaction can be carried out under normal pressure without pressurization, so that the problems of safety and economy caused by the need of a pressurization device are solved, and the synthesis method has remarkable economic advantages. In addition, the added allyl alcohol compound has an inhibition effect on byproducts which are originally generated in the reaction process. Moreover, the product is convenient to separate, pollution-free, energy-saving, environment-friendly, simple and convenient in technological operation and high in production efficiency, and can be widely used for preparing pentaerythritol allyl ether.
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Paragraph 0037-0047
(2021/04/14)
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- Preparation method of pentaerythritol triallyl ether
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The invention provides a preparation method of pentaerythritol triallyl ether and particularly relates to the technical field of synthesis of pentaerythritol triallyl ether. The method is characterized by comprising the following steps: S1, under normal pressure, feeding pentaerythritol, pentaerythritol triallyl ether, tetrabutylammonium bromide and 50% sodium hydroxide aqueous solution into a stirring reaction kettle, and heating the mixture to dissolve pentaerythritol into liquid; S2, dropwise adding chloropropene, keeping chloropropene and water evaporated, and layering the chloropropene and water after condensation, and returning chloropropene to the stirring reaction kettle; and S3, after the reaction is finished, adding water, and cooling and standing the mixture for layering, and carrying out reduced pressure distillation on the upper organic phase to obtain the product pentaerythritol triallyl ether. According to the preparation method of pentaerythritol triallyl ether providedby the invention, pentaerythritol triallyl ether is adopted as a solvent during synthesis, the addition of an inert solvent in the existing process is optimized and removed, rectification recycling or environment-friendly treatment measures of the inert solvent are not needed, and high-pressure operation of taking water as the solvent is avoided, so that the reaction is beneficial to the generation of pentaerythritol triallyl ether.
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Paragraph 0036-0052
(2020/06/16)
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- Novel cyclodextrin derivatives, method for the preparation thereof and use thereof for the solubilization of pharmacologically active substances
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The invention relates to a compound corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1 is an OH group, all R1s are identical, Z is an NHX group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element, with the proviso that the compound wherein n=1, m=6, Z=NH2 and R1=OH is excluded.
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Page/Page column 28-29
(2008/06/13)
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