- Rearrangement of S-(2-aminoethyl) thiophosphates to N-(2-mercaptoethyl)- phosphoramidates
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A novel rearrangement of S-(2-aminoethyl) thiophosphates to N-(2-mercaptoethyl)phosphoramidates was discovered and developed. The reaction proceeds smoothly at room temperature under basic conditions and the resulting thiol could subsequently be alkylated. The reaction mechanism is investigated by electron structure calculations using density functional theory at the B3LYP/6-31G(d) and B3LYP/6-311+G(d,p) levels. The calculations indicate that the reaction proceeds in a two step process when two explicit solvent molecules are included. In the presence of water the rearrangement reaction proceeds in competition with hydrolysis. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
- Chen, Menglin,Maetzke, Alice,Knak Jensen, Svend J.,Gothelf, Kurt V.
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- A protective group for indolecarboxylic group, and nucleic acid synthesis method for automatic composing nucleic acid and Amidide
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PROBLEM TO BE SOLVED: To provide a protecting group for indole group, and an amidide for automatic nucleic acid synthesis which can produce a nucleic acid stably and a precursor thereof, and a nucleic acid synthesis method.SOLUTION: Disclosed is an amidid
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Paragraph 0100; 0101
(2019/05/10)
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- Nucleic acid synthesizing dimer amidite and nucleic acid synthesizing method
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To provide an excellent dimer amidite which can be subjected to purification, preferably, whose protective groups can be removed under mild conditions, and a method for synthesizing a nucleic acid using the dimer amidite, a dimer amidite having a structur
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Page/Page column 100
(2015/01/16)
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- Amidite for synthesizing modified nucleic acid and method for synthesizing modified nucleic acid
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The disclosure provides an excellent amidite for synthesizing a modified nucleic acid, which enables a protective group therein to be removed under a moderate condition, thereby stably producing a hydroxyl group-containing modified nucleic acid. The disclosure also provides a method for synthesizing a modified nucleic acid using the amidite. Specifically, an amidite for synthesizing the modified nucleic acid is expressed by General Formula (I): where X represents a base, Y represents a substituent, Z represents a protective group for protecting a hydroxyl group in the substituent, and Q represents one of a hydrogen atom, a hydroxyl group and a hydroxyl group protected by a protective group, wherein the protective group can be removed in an aprotic solvent, and when the protective group is removed, the hydroxyl group emerges in the substituent.
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Page/Page column 18-21
(2011/04/18)
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