Highly diastereoselective alkylation of the Dellaria oxazinone template with bifunctional electrophiles
This study investigates the efficiency of alkylation of the Dellaria oxazinone glycinate template with sensitive bifunctional electrophiles. In addition to improved access to the template, triflate/halide bifunctional combinations provided good yields (85-93%) of highly diastereoselective alkylation products.
Roos, Gregory H. P.,Dastlik, Kim A.
p. 2197 - 2208
(2007/10/03)
An expedient route to the glycine templates (R)- or (S)-N-Cbz-5-phenyl-1,4-oxazin-2-one
An economical and practical route to the title compounds is described. The three step, essentially 'one pot' sequence proceeds in overall yields of up to 80% without the need for chromatography of intermediate isolation.
Dastlik, Kim A.,Giles, Robin G.F.,Roos, Gregory H.P.
p. 2525 - 2526
(2007/10/03)
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