PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS
The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).
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Paragraph 00348; 00378
(2021/12/08)
Tandem Thermal Claisen-Cope Rearrangements of Coumarate Derivatives. Total Syntheses of the Naturally Occuring Coumarins: Suberosin, Demethylsuberosin, Ostrithin, Balsamiferone and Gravelliferone
Thermal Claisen rearrangements of derivatives of 4'-O-methyl and 4'-O-benzyl methyl coumarates 3, prepared from the corresponding umbelliferone derivatives, have been investigated.Simple allyl derivatives rearrange predominantly to the vacant ortho-positi
Cairns, Nicholas,Harwood, Laurence M.,Astles, David P.
p. 3101 - 3108
(2007/10/02)
Synthesis of linear coumarins via para-Claisen rearrangement of coumarate ester derivatives: Total syntheses of suberosin, demethylsuberosin, and ostruthin