- Spectroscopic study of interaction of 1H-1,2,4-triazoline-3-thione with molecular iodine
-
The formation by 1H-1,2,4-triazoline-3-thiones in dilute chloroform solution of n-σ*-complex with molecular iodine of the composition C2H2N3S·I2 was studied by electronic spectroscopy in the UV and visible regio
- Chernovyants,Aleshina,Shcherbakov,Starikova
-
-
Read Online
- Serendipitous discovery of an efficient method for the synthesis of dimeric-RGD analogues using DMAP-photoirradiation
-
We describe a novel disulfide reaction via UV/N,N-dimethylaminopyridine (DMAP) methodology for efficient construction of alkyl and aryl symmetrical disulfides. Compared with other chemical strategies, our methodology is distinguished in that the dimerization reaction can proceed efficiently without metal catalysts, expensive reagents or forcing conditions. This methodology was successfully applied to the preparation of complex dimeric biological peptide-based molecules, and the dimeric RGD peptides produced by this methodology had better binding affinity than the commercially available E-[RGDfK]2. Our methodology will greatly extend the method to the construction of a complex disulfide bond under mild conditions.
- Zhang, Ruiping,Sun, Yao,Qiao, Ying,Li, Jianding,Xie, Jun
-
-
Read Online
- Discovery of a new fungicide by screening triazole sulfonylhydrazone derivatives and its downy mildew inhibition in cucumber
-
Downy mildew is a very important detrimental disease that lead reduced to fruits and vegetables. Due to the continuous growth of drug resistance, finding novel fungicides with dissimilar modes of function from present fungicides for controlling downy mildew are imminent. This work is an extension of our preceding research on the original triazole sulfonamide derivatives lead compound. Triazole sulfonamide as a remarkable nitrogen-containing heterocyclic compound opposed cucumber downy mildew (CDM) develops a quite vital part in the sphere of the study of new farm chemicals. The existing report designs a certain amount of 1,2,4-triazole-1,3-disulfonamide derivatives. Hydrazones have obtained extensive attention in the field of pharmaceutical due to its unique chemical structure and remarkable activity (insecticidal, antibacterial, antifungal and herbicidal). By means of coupling numerous hydrazone with triazole sulfonyl chloride groups, 24 novel derivatives were synthesized. Spectrum analysis of LC-MS, 1H NMR and 13C NMR were used for characterizing these new compounds. Compared with commercial Cyazofamid using bioassays, most of these compounds displayed preferable fungicidal activities. Moreover, compounds 8q illustrated the greatest CDM resistance (EC50 = 7.776 mg/L). Field efficacy trials revealed that compound 8q fungicidal activity was higher than the purchased agrochemical Cyazofamid and Amisulbrom. Thus, the research declared that 8q displayed a great potential for the application of fungicide against CDM.
- Gao, Guoliang,Jing, Dewang,Li, Yitao,Lin, Jian,Wu, Yang,Yao, Wenqiang
-
-
Read Online
- One-pot synthesis of disulfide-tethered ionic liquids by the reaction between 4H-1,2,4-triazole-3-thiol and α-iodoketones
-
The one-pot reaction of 4H-1,2,4-triazole-3-thiol with 1-iodopropan-2-one or 1,3-diiodopropan-2-one proceeds without solvents and basic media to afford a novel family of ionic liquids containing disulfide bridge.
- Shagun, Lyudmila G.,Dorofeev, Ivan A.,Zhilitskaya, Larisa V.,Larina, Lyudmila I.,Yarosh, Nina O.
-
-
Read Online
- Novel triazole compound and application thereof in agriculture
-
The invention provides a novel triazole compound and application thereof in agriculture. Specifically, the invention relates to a triazole compound shown as a formula (IV) and a preparation method thereof. In the formula (IV), R and R are hydrogen, C1-6 alkyl and the like, X is -CH2-, -CH(CH3)- and the like, and R, R, R, R and R are hydrogen, fluorine, chlorine, bromine, iodine, hydroxyl, cyano, nitro, amino, C1-6 alkyl and the like; the compound, a composition containing the compound and/or a preparation containing the compound have/has good bactericidal activity and can be used as a bactericide in agriculture.
- -
-
Paragraph 0135-0138
(2021/04/10)
-
- Cyclopentyl substituted disulfonamide compound and application thereof in agriculture
-
The invention belongs to the field of pesticides, and particularly relates to a cyclopentyl substituted disulfonamide compound and application thereof in agriculture. The compound is shown as a general formula (I). In the formula (I), R and R are hydrogen, C1-6 alkyl and the like, R and R are hydrogen, fluorine, chlorine, bromine or methyl, X is -CH2- and the like, and R, R, R, R and R are hydrogen, fluorine, chlorine, bromine, iodine, hydroxyl, cyano, nitro, amino, C1-6 alkyl and the like; the compound, a composition containing the compound and/or a preparation containing the compound have/has good bactericidal activity and can be used as a bactericide in agriculture.
- -
-
Paragraph 0153-0156
(2021/04/10)
-
- Triazole sulfonamides derivatives and their use in agriculture
-
The invention provides a novel triazole sulfonamide derivative and application thereof in agriculture. , The invention relates to a triazole sulfonamides derivative as shown in a formula (I) and a preparation method thereof. I In formula (R)1 And R2 Are each independently hydrogen. C1 -6 Alkyl and the like, R3 Document C3 -8 Cycloalkyl, R4 -SO2 - NRa Rb , SO2 - C1 -6 Alkyl group, SO2 - C3 -8 Cycloalkyl, SO2 - C1 -3 Alkylene - C3 -8 Cycloalkyl, SO2 - Rc , C1 -3 Alkylene - C (= O) O-C1 -6 Alkyl or - C1 -3 Alkylene - C (= O) - NRd Re , Ra , Rb , Rc , Rd And Re Having the meaning of the invention. The compound, the composition containing the compound and/or the preparation provided by the invention has good bactericidal activity and can be used as a bactericide in agriculture.
- -
-
Paragraph 0134-0137
(2021/09/26)
-
- Triazole compound and application thereof in agriculture (by machine translation)
-
More specifically, the present invention relates to a; method for, preparing a triazole compound (I) represented by formula (I) or a salt (I) thereof, a salt thereof, and a method, for producing a, triazole compound, a salt thereof, and a method for controlling a, disease by using these compounds, and or compositions in the form of a fungicide and a; fungicide ,R composition thereof. 1 , R2 , Y, n, X, R3 , R4 The, m invention has Het .the meanings as described in the present invention. (by machine translation)
- -
-
Paragraph 0218-0221
(2020/02/10)
-
- TRIAZOLE COMPOUND AND USE THEREOF IN AGRICULTURE
-
A novel triazole compound of the formula (IV) is provided, it can be used in agriculture, wherein R1 is cyclopropyl and the like; X is -CH2-and the like; each of R4 and R6 is independently hydrogen, fluorine, chlorine, CH3-, etc.; each of R3 and R7 is hydrogen, fluorine, chlorine, idoine, CH3-, -OCF3, etc.; R5 is hydrogen, fluorine, chlorine, bromine, idoine, -CF3, -OCH2CN, -OCH2CH=CH2, etc.
- -
-
Page/Page column 0091; 0092
(2020/05/13)
-
- Triazole compound and application thereof in agriculture (by machine translation)
-
The present invention provides a triazole compound; in particular, nitrogen oxide of a triazole compound represented by Formula (I) or a preparation method (I) of a triazole compound represented by Formula, and a method, of controlling diseases using these compounds or compositions in the form, of a fungicide and application, of the triazole compound and a fungicide composition thereof as fungicides . and ,R. 1 , R2 , X, n, R3 And R4 Having meanings. according to the present invention (by machine translation)
- -
-
Paragraph 0266-0269
(2020/04/01)
-
- Design, Synthesis, and Structure-Activity Relationship of Economical Triazole Sulfonamide Aryl Derivatives with High Fungicidal Activity
-
Plant fungal diseases have caused great decreases in crop quality and yield. As one of the considerable agricultural diseases, cucumber downy mildew (CDM) caused by pseudoperonospora cubensis seriously influences the production of cucumber. Amisulbrom is a commercial agricultural fungicide developed by Nissan Chemical, Ltd., for the control of oomycetes diseases that is highly effective against CDM. However, the synthesis of amisulbrom has a high cost because of the introduction of the bromoindole ring. In addition, the continuous use of amisulbrom might increase the risk of resistance development. Hence, there is an imperative to develop active fungicides with new scaffolds but low cost against CDM. In this study, a series of 1,2,4-triazole-1,3-disulfonamide derivatives were designed, synthesized, and screened. Compound 1j showed a comparable fungicidal activity with amisulbrom, but it was low cost and ecofriendly. It has the potential to be developed as a new fungicide candidate against CDM. Further investigations of structure-activity relationship exhibited the structural requirements of 1,2,4-triazole-1,3-disulfonamide and appropriate modification in N-alkyl benzylamine groups with high fungicidal activity. This research will provide powerful guidance for the design of highly active lead compounds with a novel skeleton and low cost.
- Hao, Ge-Fei,Li, Yi-Tao,Lin, Jian,Xu, Jun-Xing,Yao, Wen-Qiang,Zhou, Si
-
p. 6792 - 6801
(2020/07/08)
-
- Design, Synthesis, and Biological Activity of Novel Triazole Sulfonamide Derivatives Containing a Benzylamine Moiety
-
The triazole sulfonamide played a very important role in the field of research of new agrochemical compounds as a novel heterocyclic compound with lack of reported resistance. For the research on the innovative triazole sulfonamide fungicide effective against cucumber downy mildew (CDM), the present article designed an array of 1,2,4-triazole-1,3-disulfonamide derivatives. The derivatives were synthesized via coupling multiple benzylamine with triazole sulfonamide groups. 1H-NMR, 13C-NMR, and LC–MS spectrometry were used to characterize these synthesized compounds. Most of these derivatives exhibited better fungicidal activities than that of the commercial cyanosole using bioassays. In particular, compounds 6g and 6h showed the best fungicidal activity against CDM (EC50?=?6.91 and 10.62?mg/L). Comparative experiments demonstrated that the fungicidal activity of 6g and 6h was better than the commercial pesticides amisulbrom and cyanosole. According to the study, the compound 6g had a giant application potential on fungicide against CDM.
- Li, Yitao,Yao, Wenqiang,Lin, Jian,Li, Falin,Wu, Yang,Xu, Junxing
-
p. 2170 - 2178
(2019/07/09)
-
- Triazole compounds and their use in agriculture (by machine translation)
-
The present invention provides a triazole compound and its application in agriculture; in particular, the invention provides compounds of formula (A) indicated by the compound and its preparation method; the composition containing these compounds and preparation and their use as fungicides; wherein R1 , R2 , R3 , W, R4 , R5 , R6 , R7 , R8 , R9 , Ra , Rb And in the event of x has the meanings given by the invention. (by machine translation)
- -
-
Paragraph 0407; 0408; 0409
(2018/11/04)
-
- Intermediate compound, and synthetic method of prothioconazole
-
The invention discloses an intermediate compound, and a synthetic method of prothioconazole. The method comprises the following steps: carrying out a substation reaction on 5,5'-dithio-bis(1,2,4-triazole) and 2-(1-chlorocyclopropyl)-3-chloro-1-(2-chlorophenyl)-2-propanol to obtain the key intermediate compound; and reducing the key intermediate compound to obtain the target product prothioconazole. The synthetic method has the advantages of high conversion rate, high selectivity, cheap and easily available synthesis raw materials, reduction of the production cost, mild and easily controlled technologic reaction conditions, simplicity in operation, easiness in product purification, obtaining of the product through direct re-crystallization, simple and accurate control method of intermediates in all steps, high product yield, good atom economy, avoiding of tedious post-treatment, large competition advantages and industrial production utilization values, avoiding of strong alkalis and other raw materials, extremely low three wastes, and according with the green chemistry idea.
- -
-
Paragraph 0056; 0057; 0062; 0068; 0069; 0078; 0079
(2017/07/22)
-
- Bactericidal compound and bactericide composition and preparation and application thereof
-
The invention relates to the field of agricultural bactericides, and discloses a compound with the bactericidal activity and a bactericide composition and preparation which take the compound as an active ingredient and application of the bactericide composition and preparation.The structure of the bactericidal compound is shown as a formula (I) or a formula (II) (please see the formulas in the description).The bactericidal compound and the preparation containing the bactericidal compound have the significant prevention and control effect on cucumber downy mildew and rice sheath blight.
- -
-
Paragraph 0066; 0067; 0082; 0083
(2016/12/12)
-
- Discovery of 1,2,4-triazole-1,3-disulfonamides as dual inhibitors of mitochondrial complex II and complex III
-
Respiratory chain succinate-ubiquinone oxidoreductase (SQR or complex II) and ubihydroquinone-cytochrome (cyt) c oxidoreductase (cyt bc1 or complex III) have been demonstrated as the promising targets of numerous antibiotics and fungicides. As a continuation of our research work on the development of new fungicides, a series of 1,2,4-triazole-1,3-disulfonamide derivatives with dual functions targeting both SQR and cyt bc1 were designed and synthesized by coupling diverse diphenyl ether moieties with triazolesulfonamide units. These newly synthesized compounds were characterized by elemental analyses, 1H NMR and ESI-MS spectrometry. The in vitro assay indicated that most of the synthesized compounds displayed good inhibition against porcine succinate-cytochrome reductase (SCR) with IC50 values ranging from 3.2 to 81.8 μM, revealing much higher activity than that of the commercial control amisulbrom whose IC50 value is 93.0 μM. Further evaluation against the respective SQR and cyt bc1 indicated that most compounds exhibited SQR-inhibiting activity as well as cyt bc1-inhibiting activity, but the inhibition potency against SQR is much higher than that against cyt bc1, showing that the SCR inhibition might be contributed greatly by the SQR inhibition. The further antibacterial evaluation against Xanthomonas oryzae pv. oryzae revealed that four compounds showed excellent potency at the concentration of 20 μg mL-1. In particular, compounds 6h and 6j exhibited much better antibacterial activity than the commercial control bismerthiazol in terms of their EC50. Impressively, 6j has an EC90 of 33.62 μg mL-1, more than 10-fold higher than that of bismerthiazol.
- Cheng, Hua,Shen, Yan-Qing,Pan, Xia-Yan,Hou, Yi-Ping,Wu, Qiong-You,Yang, Guang-Fu
-
p. 7281 - 7292
(2015/09/02)
-
- Fast and highly efficient solid state oxidation of thiols
-
A fast and efficient solid state method for the chemoselective room temperature oxidative coupling of thiols to afford their corresponding disulfides using inexpensive and readily available moist sodium periodate as the reagent is described. The reaction was applicable to a variety of thiols giving high yields after short reaction times. Comparison of yield/time ratios of this method with some of those reported in the literature shows the superiority of this reagent over others under these conditions.
- Montazerozohori, Morteza,Joohari, Shiva,Karami, Bahador,Haghighat, Nasrin
-
p. 694 - 702
(2008/02/01)
-
- Gas-phase elimination reactions of 4-arylideneimino-2-cyanoethyl-1,2,4-triazol-3(2H)-ones, their thione analogues and 2-glucosyl-1,2,4-triazole-3(2H)-thiones: A kinetic and mechanistic study
-
Several 4-arylidenimino-2-cyanoethyl-1,2,4-triazol-3(2H)-ones, their 3(2H)-thiones and 2-glucosyl-1,2,4-triazol-3(2H)-thiones (1-12) were synthesized. Selective pyrolytic deprotection of these derivatives was studied in the gas phase and the kinetics of the reactions were measured for each compound. First-order rate constants measured over a 45 °C temperature range were used to calculate the Arrhenius activation parameters. A comparison of the products and the kinetic behavior of the thermal decomposition of these compounds are discussed. Copyright
- Al-Awadi, Nouria A.,Ibrahim, Yehia A.,Dib, Hicham,Kaul, Kamini
-
p. 324 - 329
(2007/10/03)
-
- Triazole sulfones having herbicidal activity
-
New herbicidal compounds are provided having the formula wherein Y is oxygen or sulfur; R1 and R2 are each independently a C1-4 hydrocarbyl group, unsubstituted or substituted with one or more halogen, haloalkyl, hydroxy, alkoxy, carboxy, amido, cyano or amino groups; or R1 and R2, together with the carbamoyl nitrogen atom to which they are attached, form a nitrogen-containing five or six membered ring, the ring being optionally interrupted by an ethereal oxygen atom and unsubstituted or substituted with one or more hydroxy, amido, cyano, amino or C1-8 alkyl, alkenyl, alkynyl, cycloalkyl, arylalkyl, alkoxy, aminoalkyl or haloalkyl groups; and R3 is hydrogen, halogen, or an alkyl, cycloalkyl, alkenyl, cycloalkenyl, cycloalkylalkenyl, aryl, arylalkyl, alkylthio or arylalkylthio group that is unsubstituted or substituted with one or more halo, hydroxy, alkoxy, acetyloxy, benzoyloxy, alkoxycarbonyl, silyl or alkylsilyl groups; or an agronomically acceptable acid addition salt or metal complex of such compound.
- -
-
-
- SYNTHESIS OF NEW THIOSULFONATES AND DISULFIDES FROM SULFONYL CHLORIDES AND THIOLS
-
Aromatic thiols were converted into thiosulfonates or disulfides, under very mild conditions, with fair to excellent yields, by using sulfonyl chloride as oxydant reagent.
- Mahieu, Jean-Pierre,Gosselet, Martine,Sebille, Bernard,Beuzard, Yves
-
p. 1709 - 1722
(2007/10/02)
-