Synthesis of Oligonucleotides Containing 2′-Deoxyisoguanosine and 2′-Deoxy-5-methylisocytidine Using Phosphoramidite Chemistry
The synthesis of oligonucleotides containing 2′-deoxy-5-methylisocytidine and 2′-deoxyisoguanosine using phosphoramidite chemistry in solid-phase oligonucleotide synthesis is described. Supporting previous observations, the N,N-diisobutylformamidine moiet
Jurczyk, Simona C.,Kodra, Janos T.,David Rozzell,Benner, Steven A.,Battersby, Thomas R.
p. 793 - 811
(2007/10/03)
Site-specific enzymatic incorporation of an unnatural base, n6-(6-ammohexyl)isoguanosine, into RNA
An efficient enzymatic method is described for the sequence-specific incorporation of a functionalizable modified base into RNA molecules. A deoxy-5-methylisocytidine (dMeisoC) in the DNA template directs the T7 RNA polymerase incorporation of
Tor, Yitzhak,Dervan, Peter B.
p. 4461 - 4467
(2007/10/02)
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