STUDIES ON THE SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 5-(3'-INDOLAL)-2-THIOHYDANTOIN DERIVATIVES AS ALDOSE REDUCTASE ENZYME INHIBITORS
A new series of 5-(3'-indolal)-2-thiohydantoin derivatives was synthesized and tested for the ability to inhibit bovine lens aldose reductase (AR) enzyme.The compounds were prepared by condensation of substituted indole-3-aldehyde derivatives with 2-thiohydantoin.The capacity of inhibiting the semi-purified bovine lens enzyme in vitro was observed for several of the compounds tested.One of them was found to be effective in reducing the enzyme activity compared with a corresponding well-known AR inhibitor.