- Cyclization of 1-acylaminoacridones into 7H-pyrido[2,3,4-kl]acridin-2(3H)- ones
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1-Acylamino-10-methylacridones in a polar aprotic solvent underwent base-catalyzed cyclization into the corresponding 7-methyl-7H-pyrido[2,3,4-kl] acridin-2(3H)-ones. Heating of 1-butylaminoacridone in acetic anhydride in the presence of p-toluenesulfonic
- Gorelik,Titova,Gordievskaya
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p. 1487 - 1491
(2007/10/03)
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- Synthesis and antiparasitic activity of new 1-nitro, 1-amino and 1-acetamido 9-acridinones
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The synthesis of 1-amino-10-alkyl-9-acridinones 4 and 5 and of homologous 9-thio-acridinones 7 and 8 are described. Similarly, the synthesis of 1-nitro-4-(2'-aminoethylamino)-9-acridinones 13 and 15, is described. Compound 4 was used as starting material for the preparation of 10-alkyl-9-acridinone dimers 6, bridged with an α,ω-diamido chain. Compound 15 was selected for biological investigations on pathogenic parasite strains, and a promising antiamoebic activity could be shown.
- Ngadi,Bsiri,Mahamoud,Galy,Galy,Soyfer,Barbe,Placidi,Rodriguez-Santiago,Mesa-Valle,Lombardo,Mascaro,Osuna
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p. 480 - 483
(2007/10/02)
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