High Turnover Pd/C Catalyst for Nitro Group Reductions in Water. One-Pot Sequences and Syntheses of Pharmaceutical Intermediates
Commercially available Pd/C can be used as a catalyst for nitro group reductions with only 0.4 mol % Pd loading. The reaction can be performed using either silane as a transfer hydrogenating agent or simply a hydrogen balloon (μ1 atm pressure). With this technology, a series of nitro compounds was reduced to the desired amines in high chemical yields. Both the catalyst and surfactant were recycled several times without loss of reactivity.
Gallou, Fabrice,Li, Xiaohan,Lipshutz, Bruce H.,Takale, Balaram S.,Thakore, Ruchita R.
supporting information
p. 8114 - 8118
(2021/10/25)
Second-generation process research towards eletriptan: A fischer indole approach
The development of a second-generation process for the synthesis of eletriptan via a Fischer indole cyclisation is described. The finalised process offers several potential advantages over the current route of manufacture including cost, throughput, and safety.
Ashcroft, Christopher P.,Pettman, Alan,Watkinson, Simon,Hellier, Paul
p. 98 - 103
(2011/09/16)
MODIFIED FISCHER INDOLE SYNTHESIS OF ELETRIPTAN
The present invention relates to a new process for the preparation of eletriptan (I), or its enantiomer comprising a modified Fischer indole synthesis, namely the reaction of a compound of formula (II), wherein R1 is a suitable hydrazine protecting group, with a compound of formula (III) wherein R2is an aldehyde group (-CHO) or the functional equivalent thereof.
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Page/Page column 16-17
(2010/02/14)
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