- Synthesis and biophysical properties of (l)-aTNA based G-quadruplexes
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Novel G-quadruplex structures are constructed by acyclic (l)-threninol nucleic acid and their synthesis and biophysical properties are described. Pyrene excimer fluorescence and circular dichroism (CD) data revealed that four strands of aTNA are oriented
- Kumar, Vipin,Gothelf, Kurt V.
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p. 1540 - 1544
(2016/02/10)
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- DOTASQ as a prototype of nature-inspired G-quadruplex ligand
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DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-m
- Stefan, Loic,Guedin, Aurore,Amrane, Samir,Smith, Nicole,Denat, Franck,Mergny, Jean-Louis,Monchaud, David
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p. 4992 - 4994
(2011/06/10)
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- NEW SYNTHONS FOR THE SYNTHESIS OF CHIRAL PEPTIDE NUCLEIC ACIDS AND METHODS FOR PREPARING THE SAME
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Novel l-acyl-3-amino-4-hydroxymethylpyiτolidine derivatives useful as PNA synthons optionally having protecting groups suitable of removal under mild conditions are disclosed having the formula (E) wherein: R1 is H or R-C(=O), wherein R is stra
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Page/Page column 64
(2008/12/08)
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- Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
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A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.
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- Synthetic procedures for peptide nucleic acids
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A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
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- Peptide nucleic acids having 2,6-diaminopurine nucleobases
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A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8alkylamine side chains.
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- Linked peptide nucleic acids
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Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.
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- Peptide nucleic acids
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Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.
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- PEPTIDE NUCLEIC ACID CONJUGATES
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A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
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- Cyclic PNA hexamer-based compound: Modelling, synthesis and inhibition of the HIV-1 RNA dimerization process
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A cyclic molecule constituted by (i) a hexameric PNA moiety complementary to six among the nine residues of the dimerization initiation site loop of HIV-1 and (ii) a spacer tethering the N- to the C-extremities of the PNA, has been elaborated to inhibit the dimerization process of HIV-1 genome. This compound has been synthesized following a liquid-phase procedure (fully protected backbone approach). Preliminary agarose gel electrophoresis analyses have shown that the cyclic PNA conjugate is able to inhibit the HIV-1 dimerization.
- Schwergold, Caroline,Depecker, Geoffrey,Giorgio, Christophe Di,Patino, Nadia,Jossinet, Fabrice,Ehresmann, Bernard,Terreux, Raphael,Cabrol-Bass, Daniel,Condom, Roger
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p. 5675 - 5687
(2007/10/03)
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- Double-stranded peptide nucleic acids
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A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
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- Chiral peptide nucleic acid monomers and oligomers
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A novel class of peptide nucleic acid monomers are synthesized having chirality in the backbone. Peptide nucleic acid oligomers are synthesized to incorporate these chiral monomers.
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- Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
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A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C1 -C8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.
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- Peptide nucleic acids having amino acid side chains
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A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.
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- Peptide nucleic acids
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A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
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- Liquid phase synthesis of a peptidic nucleic acid dimer
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The first liquid phase synthesis of a peptidic nucleic acid (PNA) dimer containing guanine and adenine has been achieved in good yields. A new strategy was elaborated in order to circumvent difficult coupling of the protected PNA.
- Farese, Audrey,Patino, Nadia,Condom, Roger,Dalleu, Sandrine,Guedj, Roger
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p. 1413 - 1416
(2007/10/03)
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- Synthesis of Peptide Nucleic Acid Monomers Containing the Four Natural Nucleobases: Thymine, Cytosine, Adenine, and Guanine and Their Oligomerization
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The preparation of mixed-sequence PNAs (PNAs containing the four natural nucleobases; thymine, cytosine, adenine, and guanine) is described.The PNA monomers containing thymine, Cbz-protected cytosine, or adenine or benzyl-protected guanine were prepared v
- Dueholm, Kim L.,Egholm, Michael,Behrens, Carsten,Christensen, Leif,Hansen, Henrik F.,et al.
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p. 5767 - 5773
(2007/10/02)
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- Peptide Nucleic Acids containing Adenine or Guanine recognize Thymine and Cytosine in Complementary DNA Sequences
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Peptide nucleic acid (PNA) monomer building blocks for the introduction of G and A are prepared and used to synthesise H-T4XT5-Lys-NH2 (X=G or A), which are shown by Tm measurements to recognize their complementary DNA sequences in both the parallel (N-te
- Egholm, Michael,Behrens, Carsten,Christensen, Leif,Berg, Rolf H.,Nielsen, Peter E.,Buchardt, Ole
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p. 800 - 801
(2007/10/02)
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