- Optimized methods for preparation of 6I-(ω-sulfanyl-alkylenesulfanyl)-β-cyclodextrin derivatives
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A general high-yielding method for the preparation of monosubstituted β-cyclodextrin derivatives which have attached a thiol group in position 6 is described. The thiol group is attached through linkers of different lengths and repeating units (ethylene glycol or methylene). The target compounds were characterized by IR, MS and NMR spectra. A simple method for their complete conversion to the corresponding disulfides as well as a method for the reduction of the disulfides back to the thiols is presented. Both, thiols and disulfides are derivatives usable for well-defined covalent attachment of cyclodextrin to gold or polydopamine-coated solid surfaces.
- Bedná?ová, Eva,Hybelbauerová, Simona,Jind?ich, Jind?ich
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- Synthesis of dicycloheptano- and dicyclooctanothiacrown ethers their properties as extractants
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12- and 15-Membered thia- and oxathiacrown ethers and podands containing cycloheptane and cyclooctane fragments have been synthesized. The properties of the synthesized compounds as extractants for Ra2+ and Pd2+ ions have been studied.
- Nasyrov,Bobyleva,Abramov,Anfilogova,Vasil'Kov,Anisimov
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- Synthesis of acyclic, symmetrical 3,3'-allyl dithioethers, from the alkylation of 3-mercapto-2-mercaptomethylprop-1-ene in the presence of sodium hydride
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A novel method where 3,3'-allyl dithioethers have been prepared from 3-mercapto-2-mercaptomethylprop-1-ene and two mol equivalent of alkyl halide in the presence of two mol equivalent of sodium hydride has been developed. Using this method, bisepoxide, 2,2'-(2-methylenepropane-1,3-diyl)bis(sulfanediyl) bis(methylene)dioxirane (8) has been synthesized from epichlorohydrin, whereas potassium carbonate was unable to deliver this product. These 3,3'-allyl dithioethers can be utilized either as monomers, or with further chemical reactions transformed into more complex monomers, for photoplastic polymer networks.
- Moorhoff, Cornelis M.,Cook, Wayne D.,Chen, Fei,Nghiem, Dat,Braybrook, Carl,Thang, San H.,Sun, Jiazeng,Scott, Timothy F.,Bowman, Christopher N.
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- The synthesis and complexation studies of thia-anthracene receptors
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Systematic studies towards the formation of thia-anthracene receptors were performed. Anthracene podand 3 consisting of two anthryl groups connected by the SCH2CH2CH2S spacer group was prepared in 99% yield. The complexation properties of this compound were investigated using UV-VIS and fluorescence titration techniques. Addition of silver salts into a solution of the fluorophore strongly modifies the absorption and fluorescence spectra and the association constants were found to be K1 = 2 x 105 and K2 = 8 x 104 M-1 for the 1:1 and 1:2 complexes, respectively. Addition of metal ions, as Cu2+ Zn2+, Cd2+, Hg2+, Ni2+, and Co2+, did not lead to any change in the photophysical properties of compound 3.
- Ostaszewski, Ryszard,Prodi, Luca,Montalti, Marco
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- Photochromic controlled permeable small molecule cross-linked vesicle as well as preparation method and application thereof
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The invention discloses a photochromic controlled-permeation small-molecule crosslinked vesicle CSMVs as well as a preparation method and application thereof. Belong to micromolecule self-assembly technical field. The invention firstly synthesizes an azobenzene amphiphilic compound, and then further cross-linking to prepare the photochromic controllable permeable small-molecule cross-linked vesicle. The controlled release system is simple to prepare, high in stability, intelligent in control, and capable of exhibiting real-time controllable permeability in time and space, CSMVs at the molecular level due to the molecular structure of the vesicle wall, and instantaneous controlled release is exhibited. In cancer. The method has wide application prospects in the accurate treatment of diseases such as diabetes and bacterial infection.
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Paragraph 0045-0046; 0048
(2021/09/01)
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- Application of HPLC for the screening of separation of new macrocyclic systems
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The efficient synthesis of new macrocyclic systems via nucleophilic ring opening reaction of epoxides by thiols was described. Initially new macrocyclic compounds were obtained as a mixture of diastereomers. Preparative thin layer chromatography was applied to separate meso and pairs of enantiomer. The identification of products using a chiral HPLC column and mass spectroscopy was utilized.
- Stefaniak, Monika,Romański, Jaros?aw
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p. 245 - 248
(2017/01/22)
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- Conversion of alcohols to thiols via tosylate intermediates
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High yielding syntheses of mercapto terminated mono-disperse dimer, trimer, and tetramer ethyleneoxide oligomers and of p-hydroxyphenethyl thiol via an alcohol-tosylate-thiol route are reported. Comparisons are made with the more conventional alcohol-bromide-thiol route.
- Snow, Arthur W.,Foos, Edward E.
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p. 509 - 512
(2007/10/03)
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- Synthesis of 12- and 13-membered sulfur-containing lactones by homolytic macrocyclization of mercaptoacetic esters with alkynes
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Starting from mercaptoacetic acid esters of 1,2- or 1,3-diols and substituted acetylenes 12- and 13-membered sulfur-containing lactones as 1:1 adducts were synthesised in yields up to 48%. The mechanism of this homolytic reaction, which is initiated by the tripropylborane/oxygen system, includes generation of thiyl radicals and their addition to the triple bond of alkynes.
- Demchuk,Lazareva,Lindeman,Khrustalyov,Struchkov,Ismagilov,Troyansky,Nikishin
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p. 307 - 311
(2007/10/02)
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- Process for the preparation of 2-mercaptoalkyl-sulphides and 2-mercaptoalkylethers
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2-Mercaptoalkylsulphides and 2-mercaptoalkylethers are obtained by the hydrazinolysis of 3-thiaalkylisothiuronium salts and 3-oxaalkylisothiuronium salts.
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