- Preparation method of cloperadine hydrochloride
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The invention relates to a preparation method of cloperadine hydrochloride, which comprises the following steps: placing a formula VI and a formula III in a solvent or without a solvent, carrying out condensation or etherification reaction, and separating to obtain 1-[2-[(4-chloro-alpha phenyl benzyl) oxygen] ethyl] piperidine (II); and salifying the 1-[2-[(4-chloro-alpha phenyl benzyl) oxygen] ethyl] piperidine with hydrogen chloride or hydrochloric acid in a solvent to obtain the cloperadine hydrochloride. The method is mild in process condition, convenient and simple to operate and suitable for large-scale industrial production, the purity of the produced target product reaches 99.7% or above, and the single impurity is smaller than 0.1%.
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Paragraph 0041-0046
(2021/11/19)
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