- PREPARATION AND SPECTRAL PROPERTIES OF IMIDAZO- AND TRIAZOLOQUINOLINES WITH ANGULAR RING FUSION
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The imidazo- and triazoloquinolines (Va, Vb) and imidazo- and triazoloquinolines (Xa, Xb) have been synthetized by the Gould-Jacobs reaction starting from the quinolinecarboxylic acids II and VII prepared by base catalyzed hydrolysis of the esters I and VI, resp.The decarboxylation of the acids II and VII gives the quinolones III and VIII, resp., which are aromatized to the corresponding chloroquinolines IV and IX.The latter compounds give the azoloquinolines V and X on catalytic reduction.The structure of the condensed heterocyclic compounds with angular ring fusion has been proved by 1H and 13C NMR, IR, UV, and mass spectra.
- Milata, Viktor,Ilavsky, Dusan,Lesko, Jan
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p. 1068 - 1077
(2007/10/02)
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- Substances inhibiting amine oxidases. III. Synthesis and amine oxidase inhibition of imidazoquinoline derivatives
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The activity of copper and FAD dependent amine oxidases was tested with some derivatives of 3H-imidazo[4,5-h]quinoline and its isomers 3H-imidazo[4,5-f]quinoline, the chemistry of which is described in the literature (1), and Ki calculated. The methyl derivative of 3H-imidazo[4,5-f]quinoline was found to activate the copper bovine serum enzyme, but inhibits the FAD mitochondrial enzyme.
- Chimenti,Bolasco,Vomero,Casanova,Befani,Sabatini,Turini,Mondovì,Gagliardi
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p. 513 - 524
(2007/10/02)
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