cas 150728-12-4, 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione | Articles data ｜lookchem

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150728-12-4

Articles about 150728-12-4Total 4 be found

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A method for the treatment of pulmonary arterial hypertension drug preparation method
The invention provides a preparation method of a therapeutic medicine for treating pulmonary arterial hypertension and particularly provides a preparation method of a key intermediate compound as shown in a formula (IV). According to the method, the compound as shown in the formula (IV) is obtained by means of reaction of a compound as shown in a formula (II) and a compound as shown in a formula (III). The preparation method is easily available in raw materials, low in cost, mild in condition and suitable for industrialized production. The formulae (IV), (II) and (III) are as shown in the specification.
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Paragraph 0112; 0122; 0130-0132

(2017/10/07)

Improved Large-Scale Synthesis of Bosentan Monohydrate
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Raju, K. Rajasekhara,Reddy, B. Shankar,Somannavar,Sinha,Babu, P. N. Kishore,Raju, K. Mohana
p. 481 - 491
(2016/11/09)

PROCESS FOR PREPARATION OF ENDOTHELIAL RECEPTOR ANTAGONIST (BOSENTAN)
The present invention relates to processes for the preparation of an endothelial receptor antagonist. The present invention particularly relates to synthesis of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide (bosentan).
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Page/Page column 6-7

(2012/06/16)

SUBSTITUTED PYRIMIDINES
Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
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Page/Page column 32; 34

(2008/12/07)

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Chemical Properties

Density: 1.459 g/cm³
Storage Temp.:2-8°C
PKA: 6.23±0.40(Predicted)
PSA: 102.77000
LogP: 0.10020

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