cas 151169-74-3, 2,3-Dichlorophenylboronic acid | Articles data ｜lookchem

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151169-74-3

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Pyrazine compounds
A compound of formula (I) wherein R1is selected from the group consisting of phenyl substituted by one or more halogen atoms, naphthyl and naphthyl substituted by one or more halogen atoms; R2is selected from the group consisting of —NH2and —NHC(═O)Ra; R3is selected from the group consisting of —NRbRc, —NHC(═O)Raand hydrogen, R4is selected from the group consisting of hydrogen, -C1-4alkyl, -C1-4alkyl substituted by one or more halogen atoms, —CN, —CH2OH, —CH2ORdand —CH2S(O)xRd; wherein Rarepresents C1-4alkyl or C3-7cycloalkyl, and Rband Rc, which may be the same or different, are selected from hydrogen and C1-4alkyl, or together with the nitrogen atom to which they are attached, form a6-membered nitrogen containing heterocycle, which heterocycle can be further susbtituted with one or more C1-4alkyl; Rdis selected from C1-4alkyl or C1-4alkyl substituted by one or more halogen atoms; x is an integer zero, one or two; and pharmaceutically acceptable derivatives thereof; with the proviso that R1does not represent (a); when R2is —NH2, and both R3and R4are hydrogen.
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(2008/06/13)

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Chemical Properties

Appearance/Colour :white powder
Melting Point: 125 °C (dec.)(lit.)
Boiling Point: 349.8 °C at 760 mmHg
Flash Point:165.4 °C
Density: 1.47 g/cm³
Solubility:Soluble in methanol.
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
Vapor Pressure: 1.71E-05mmHg at 25°C
Refractive Index: 1.577
PKA: 7.26±0.58(Predicted)
PSA: 40.46000
LogP: 0.67320

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