- Selenazole diphosphonic acid compound and preparation method thereof
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The invention belongs to the technical field of medicines, and discloses a selenazole diphosphonic acid compound and a preparation method thereof, the structural characteristics of the compound are identified, the selenazole diphosphonic acid compound has
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Paragraph 0025
(2021/01/15)
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- Linking bisphosphonates to the free amino groups in fluoroquinolones: Preparation of osteotropic prodrugs for the prevention of osteomyelitis
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Osteomyelitis is an infection located in bone and a notoriously difficult disease to manage, requiring frequent and heavy doses of systemically administered antibiotics. Targeting antibiotics to the bone after systemic administration may provide both grea
- Houghton, Tom J.,Tanaka, Kelly S. E.,Kang, Ting,Dietrich, Evelyne,Lafontaine, Yanick,Delorme, Daniel,Ferreira, Sandra S.,Viens, Frederic,Arhin, Francis F.,Sarmiento, Ingrid,Lehoux, Dario,Fadhil, Ibtihal,Laquerre, Karine,Liu, Jing,Ostiguy, Valérie,Poirier, Hugo,Moeck, Gregory,Parr Jr., Thomas R.,Far, Adel Rafai
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experimental part
p. 6955 - 6969
(2009/11/30)
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- Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections
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The present invention relates to phosphonated fluoroquinolones, antibacterial analogs thereof, and methods of using such compounds. These compounds are useful as antibiotics for prevention and/or the treatment of bone and joint infections, especially for the prevention and/or treatment of osteomyelitis.
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Page/Page column 84-85
(2008/12/09)
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- Herbicidal aza bisphosphonic acids and compositions containing the same
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Herbicidal compositions containing a bisphosphonic acid compound of the formula STR1 wherein n is 0, 1, 2, 3, 4, 5 or 6, or an agrochemically acceptable salt or hydrolyzable ester thereof and methods of controlling undesirable plant growth using these bis
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- Steroid derivatives
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Asteroid derivative of the general formula: STR1 wherein X--O-- represents a residue of steroid compound and --A-- represents --CO[NH(CHR1)y --(Y)p --CO]m NH--, --CO--(R2)x --(Z)q --CO--NH--, or --CO--(CH2)n --. A therapeutic agent to osteopathy comprising the above steroid derivative is also provided.
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- SYNTHESE DE CONJUGUES GEM-BISPHOSPHONIQUES DE DERIVES DE LA CORTISONE
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Some gem-bisphosphonic cortico-steroid conjugates are prepared by esterification between gem-bisphosphonate carboxylic acids and steroid primary alcohols.These original products take place in a biological study about a delivery-targeting concept of active constituents in bone therapy, with the assistance of gem-bisphosphonic building-blocks. Key words: gem-bisphosphonate; gem-bisphosphonic; tetraethyl ethylidene gem-bisphosphonate; corticosteroids; esterification; anti-inflammatory; delivery-targeting concept.
- Guervenou, J.,Sturtz, G.
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