- PROCESS FOR THE PREPARATION OF DICLOFENAC EPOLAMINE
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The present invention concerns a process for the preparation of the salt diclofenac epolamine comprising the following steps: a) reacting 1 -(2,6-dichlorophenyl)-2-indolinone with a base selected from sodium hydroxide or potassium hydroxide in an aqueous solvent, thus obtaining sodium or potassium diclofenac salt; b) dissolving the so obtained sodium or potassium diclofenac salt in a solvent- mixture comprising water and an organic solvent selected from the group consisting of ethyl acetate, methyl isobutyl ketone, toluene, isobutyl acetate, n-butyl acetate, n-propyl acetate, isopropyl acetate; c) adding a strong acid to give diclofenac acid and removing the water phase; d) anhydrifying the remaining organic solvent phase; and e) adding 1-(2-hydroxyethyl)-pyrrolidine.
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Page/Page column 8-9
(2010/08/05)
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