cas 15397-12-3, 2'-C-Methyladenosine | Articles data

Articles about 15397-12-3Total 11 be found

A concise synthesis of 2'-C-methylribonucleosides
2'-C-methylribonucleosides were synthesized in five steps from commercially available 1,3,5-tri-O-benzoyl-α-D-ribose with good overall yields.
Wolfe,Harry-O'kuru
p. 7611 - 7614
(1995)
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CYCLIC DINUCLEOTIDES AS STING AGONISTS
Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R1A, R1B, R1C, R1D, B1, R2A, R2B, R2C, R2D, and R2E are defined herein and Formula (II), wherein R1H, R1K, R1J, and R2L are defined herein.
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Page/Page column 51; 55

(2018/08/20)

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae and/or Flaviviridae viral infections with one or more nucleotide analogs.
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Paragraph 0381

(2018/03/06)

METHODS AND COMPOSITIONS FOR TREATING HEPATITIS C VIRUS
The present invention provides pharmaceutical compositions for the treatment of a hepatitis C infection in a host, comprising an antivirally effective amount of a 2'-C-branched nucleoside or a 2'-C-branched ribofuranosyl nucleoside, or pharmaceutically acceptable salts or esters thereof, in combination with one or more other anti-HCV agent. The present invention further provides the use of a 2'-C-branched nucleoside or a 2'-C-branched ribofuranosyl nucleoside, or pharmaceutically acceptable salts or esters thereof, in the manufacture of a medicament for the treatment of a hepatitis C infection in a host.
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Paragraph 0132; 0133

(2017/03/08)

The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus
β-2′-C-Methyl purines (1, 2) are known inhibitors of hepatitis C virus (HCV). We herein report the synthesis, biological and enzymatic evaluation of their 5′-phosphoramidate ProTides. Described herein are seven l-alanine phosphoramidate derivatives with v
McGuigan, Christopher,Perrone, Plinio,Madela, Karolina,Neyts, Johan
scheme or table
p. 4316 - 4320
(2010/06/19)

CHEMICAL COMPOUNDS
Phosphoramidate derivatives of nucleoside compounds derived from bases such as adenine and guanine have enhanced therapeutic potency, in particular, enhanced potency with respect to the prophylaxis or treatment of a viral infection such as hepatitis C vir
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Page/Page column 19-20

(2008/12/05)

2'-C-Methyl analogues of selective adenosine receptor agonists: Synthesis and binding studies
2'-C-Methyl analogues of selective adenosine receptor agonists such as (R)-PIA, CPA, CCPA, NECA, and IB-MECA were synthesized in order to further investigate the subdomain that binds the ribose moiety. Binding affinities of these new compounds at A1
Franchetti, Palmarisa,Cappellacci, Loredana,Marchetti, Stefano,Trincavelli, Letizia,Martini, Claudia,Mazzoni, Maria R.,Lucacchini, Antonio,Grifantini, Mario
p. 1708 - 1715
(2007/10/03)

2′-C-alkylribonucleosides: Design, synthesis, and conformation
Certain 2′-C-alkylribonucleotides have been designed as potential mechanism-based inactivators of ribonucleotide reductases. A short, flexible route toward the corresponding nucleosides and NMR evidence concerning their preferred solution conformations are discussed. Copyright
Harry-O'kuru, Rogers E.,Kryjak, Emily A.,Wolfe, Michael S.
p. 1457 - 1460
(2007/10/03)

A short, flexible route toward 2'-C-branched ribonucleosides
A five-step synthesis of 2'-C-branched ribonucleosides from commercially obtained 1,3,5-tri-O-benzoyl-α-D-ribofuranose (4) is described. The free hydroxyl group of 4 was oxidized in high yield with Dess-Martin periodane reagent. The resultant 2-ketosugar was treated with MeMgBr/TiCl4, CH2=CHMgBr/CeCl3, or TMSC≡CLi/CeCl3, and in each case addition to the ketone proceeded stereoselectively to provide 2-alkylated ribofuranosides. After conversion to the corresponding tetrabenzoyl derivatives, the 2-alkylribofuranosides were coupled to nucleobases under Vorbruggen persilylation conditions, giving the β-nucleosides with high stereoselectivity. Deprotection with methanolic ammonia provided the title compounds in 17-49% overall yields from 4.
Harry-O'kuru,Smith,Wolfe
p. 1754 - 1759
(2007/10/03)

New 2'-branched-chain sugar nucleoside analogs with potential antiviral or antitumor activity
The synthesis of 2'-C-hydroxymethyl and 2'-C-methyl nucleoside analogs [1-(3-deoxy-2-hydroxymethyl-D-erythro-pentofuranosyl)thymine (14), the corresponding adenine derivative. 17, 1-(2-methyl-β-D-ribofuranosyl)thymine (20) and 2'-methyladenosine (23)] by
Wolf,Jarrige,Florent,Grierson,Monneret
p. 773 - 778
(2007/10/02)

NEW SYNTHESES OF 2'-C-METHYLNUCLEOSIDES STARTING FROM D-GLUCOSE AND D-RIBOSE
Effective general methods have been developed for the synthesis of 2'-C-methylnucleosides starting from D-glucose and D-ribose. 3-O-Benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-allofuranose was prepared in 5 steps from D-glucose and converted into 1,2,3-tri
Beigelman, Leon N.,Ermolinsky, Boris S.,Gurskaya, Galina V.,Tsapkina, Elena N.,Karpeisky, Marat Ya.,Mikhailov, Sergey N.
p. 219 - 232
(2007/10/02)