- Glycerol as an alternative green reaction medium for multicomponent reactions using PS-PEG-OSO3H as catalyst
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Development of green solvents from renewable resources has gained much attention recently, because of the extensive uses of solvents in almost all of the chemical industry and the predicted disappearance of fossil oil. Here we show that glycerol and PS-PE
- Quan, Zheng-Jun,Ren, Rong-Guo,Da, Yu-Xia,Zhang, Zhang,Wang, Xi-Cun
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Read Online
- Ruthenium(III) chloride-catalyzed one-pot synthesis of 3,4- dihydropyrimidin-2-(1H)-ones under solvent-free conditions
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Ruthenium(III) chloride efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a β-keto ester, and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidine-2-(1H) -ones in excellent yields. Geo
- De, Surya K.,Gibbs, Richard A.
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Read Online
- Biginelli reaction in aqueous medium: a greener and sustainable approach to substituted 3,4-dihydropyrimidin-2(1H)-ones
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An environmentally benign aqueous Biginelli protocol for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using polystyrenesulfonic acid (PSSA) as a catalyst has been achieved. These microwave-assisted reactions proceed efficiently in water in
- Polshettiwar, Vivek,Varma, Rajender S.
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Read Online
- Silica gel-supported polyphosphoric acid (PPA-SiO2) catalyzed one-pot multi-component synthesis of 3, 4-dihydropyrimidin-2(1H)-ones and -thiones: An efficient method for the Biginelli reaction
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A green and efficient method for the synthesis of 3, 4-dihydropyrimidin- 2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphor
- Zeinali-Dastmalbaf, Mohsen,Davoodnia, Abolghasem,Heravi, Majid M.,Tavakoli-Hoseini, Niloofar,Khojastehnezhad, Amir,Zamani, Hassan Ali
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Read Online
- Deep eutectic solvent assisted synthesis of dihydropyrimidinones/thionesviaBiginelli reaction: theoretical investigations on their electronic and global reactivity descriptors
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Deep eutectic solvents formed from hydrated metal chlorides and hydrogen bond donors (Type 4) were prepared and their catalytic activity was compared for the synthesis of dihydropyrimidinones/thionesviaBiginelli reaction at room temperature. The one-pot m
- Shaibuna,Kuniyil, Muhammed Jeneesh Kariyottu,Sreekumar
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p. 20765 - 20775
(2021/11/23)
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- Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives
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Simple ammonium ionic liquids [ILs] are efficient, green, environmentally friendly catalysts in promoting the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction to afford 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives respectively by eliminating the need for harmful volatile organic solvents. These [ILs] are air and water stable, easy to prepare and cost-effective. The effects of the anions and cations present in [IL] on reactions were investigated. The results clearly indicated that the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction were heavily influenced by the acidity of [IL], and among various ammonium ionic liquids, [Et3NH][HSO4] showed the best catalytic activity. Furthermore, [IL] could be easily separated and reused with a slight loss of its activity. This technique provided a good alternative way for the industrial synthesis of 1,2,3,4-tetrahydropyrimidinones, 2-aminothiazoles and quinazolinones. The present processes are eco-friendly methods for the synthesis of these derivatives authenticated by several green parameters, namely,E-factor, process mass intensity, reaction mass efficiency, atom economy, and carbon efficiency.
- Kakati, Praachi,Singh, Preeti,Yadav, Priyanka,Awasthi, Satish Kumar
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p. 6724 - 6738
(2021/04/22)
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- Sulfonic Acid and Ionic Liquid Functionalized Covalent Organic Framework for Efficient Catalysis of the Biginelli Reaction
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A quinoline-linked and ionic liquid-decorated covalent organic framework was prepared by incorporation of a multicomponent Povarov reaction and postsynthetic modification. The imidazolium and sulfonic acid-decorated COF-IM-SO3H can be a highly efficient B
- Yao, Bing-Jian,Wu, Wen-Xiu,Ding, Luo-Gang,Dong, Yu-Bin
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p. 3024 - 3032
(2021/02/05)
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- Poly(N-vinyl-2-pyrrolidone)-supported ferric chloride: An effective reusable heterogeneous catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via three-component Biginelli reaction
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An environmentally benign three-component Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed.
- Donyapeyma, Ghazaleh,Rahmatpour, Ali
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- Amino acid ionic liquid-catalyzed synthesis, anti-Leishmania activity, molecular docking, molecular dynamic simulation, and ADME study of 3,4-dihydropyrimidin-2(1H)-(thio)ones
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The synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one (DHPM) derivatives involving aromatic aldehyde, β-ketoesters and urea/thiourea using prolinium hydrogen sulfate (ProHSO4) as a catalyst has been studied. A variety of DHPM derivatives were o
- Patil, Rajendra,Rode, Nitin,Shelar, Amruta,Tantray, Aafaq,Terdale, Santosh
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supporting information
(2021/12/22)
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- Green synthesis, structural analysis and anticancer activity of dihydropyrimidinone derivatives
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In this study, for the first time, we have used Citrus macroptera juice to synthesize dihydropyrimidine (DHPM) derivatives via the Biginelli reaction, which showed better yield, shorter reaction time, and did not require an organic solvent for the reactio
- Dowarah, Jayanta,Marak, Brilliant N.,Patel, Devanshi,Shah, Pramod Kumar,Shukla, Pradeep Kumar,Singh, Ved Prakash,Yadav, Umesh Chand Singh
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p. 35737 - 35753
(2021/12/02)
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- Synthesis method of dihydropyrimidinone compound
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The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a
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Paragraph 0034-0036; 0040-0041; 0044; 0070-0075; 0081
(2021/05/19)
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- Efficient one-pot synthetic methods for the preparation of 3,4-dihydropyrimidinones and 1,4-dihydropyridine derivatives using BNPs?SiO2(CH2)3NHSO3H as a ligand and metal free acidic heterogeneous nano-catalyst
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Heterocyclic compounds with biological and pharmacological activates like 3,4-dihydropyrimidin-2-(1H)-ones and 1,4-dihydropyridines have attracted great interest. Boehmite nanoparticles functionalized with silylpropyl sulfamic acid (BNPs?SiO2(C
- Bahrami, Kiumars,Khodamorady, Minoo,Sohrabnezhad, Samira
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- Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation
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Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan
- Godugu, Kumar,Gundala, Trivikram Reddy,Mohinuddin Pinjari, Mohammad Khaja,Reddy Nallagondu, Chinna Gangi,Sanapareddy, Lakshmi Reddy,Sri Yadala, Venkata Divya
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supporting information
p. 1881 - 1900
(2020/10/02)
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- Air-stable zirconium (IV)-salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions
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An air-stable complex of zirconium (IV)-salophen perfluorooctanesulfonate (1) was successfully synthesized by reacting Zr (salphen)Cl2 and C8F17SO3Ag. Complex 1 was characterized and studied by different techniq
- Li, Ningbo,Wang, Yijun,Liu, Feijun,Zhao, Xin,Xu, Xinhua,An, Quan,Yun, Keming
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- CoNiFe2O4@Silica-SO3H nanoparticles: New recyclable magnetic nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions
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A useful and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives were achieved by one-pot cyclocondensation between substituted aryl aldehydes, diketone/ketoester, and urea/thiourea using magnetic CoNiFe2O4@Silica-
- Karimian, Azam,Rad, Masoud Saadati,Mahdavi, Elham
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p. 1702 - 1714
(2020/09/07)
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- Synthesis and characterization of the immobilized polythiophene on magnetic carbon nanotube as a prominent catalyst for the synthesis of dihydropyrimidinone and octahydroquinazolinone derivatives
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Abstract: In this work, the immobilized polythiophene on magnetic carbon nanotube (CNT–Fe3O4–PTh) was synthesized and introduced as a novel and recoverable catalytic system. The prepared magnetic heterogeneous nanocatalyst was characterized by FT-IR, TGA, EDX, VSM, XRD, TEM, and FE-SEM. Next, the catalytic efficiency of CNT–Fe3O4–PTh was evaluated through the green synthesis of a variety of dihydropyrimidinone and octahydroquinazolinone through Biginelli reaction between aromatic aldehydes, urea/thiourea, and β-dicarbonyl compounds under solvent-free conditions. The catalyst was magnetically recovered and recycled for five cycles without a discernible loss in its catalytic activity. Simple workup, affordability, short reaction times, mild reaction conditions, and the high yield of products are the interesting features of this project. Graphic abstract: An environmentally benign nanocomposite was prepared using carbon nanotube as an inexpensive, nontoxic, and stable support in the preparation of CNT–Fe3O4–PTh, which was efficiently used as catalyst for the green synthesis of dihydropyrimidinone and octahydroquinazolinone derivatives through Biginelli reaction under solvent-free conditions.[Figure not available: see fulltext.].
- Akbarzadeh, Parisa,Koukabi, Nadiya
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p. 4955 - 4969
(2020/08/19)
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- Concentrated solar radiation as a renewable heat source for a preparative-scale and solvent-free Biginelli reaction
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A well-known Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones was performed in an environmentally responsible manner. Large numbers of substrates were screened, and found to give excellent yields of the desired products. In
- Gadkari, Yatin U.,Hatvate, Navnath T.,Takale, Balaram S.,Telvekar, Vikas N.
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supporting information
p. 8167 - 8170
(2020/06/09)
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- Solvent and catalyst free synthesis of 3,4-dihydropyrimidin-2(1: H)-ones/thiones by twin screw extrusion
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This report describes the synthesis of a few 3,4-dihydropyrimidin-2(1H)-ones/thiones using a twin screw extruder. Use of the extruder allowed the reaction to be carried out without a catalyst or solvent. Twin screw extrusion can also be executed as a cont
- Carvalho, Reyniel Ben,Joshi, Shreerang V.
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supporting information
p. 1921 - 1924
(2019/04/29)
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- A nanocrystalline CdS thin film as a heterogeneous, recyclable catalyst for effective synthesis of dihydropyrimidinones and a new class of carbazolyl dihydropyrimidinones: Via an improved Biginelli protocol
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This is the first report on the use of a nanocrystalline cadmium sulphide (CdS) thin film coated glass reactor as an efficient tool for the synthesis of dihydropyrimidinones via multicomponent reactions of aldehydes, a β-ketoester, and urea/thiourea in et
- Venkatapathy,Magesh,Lavanya,Perumal,Sathishkumar
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p. 10989 - 11002
(2019/07/15)
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- Efficient Catalytic Synthesis of 3,4-Dihydropyrimidin-2-ones/thiones via Little Acidic Ionic Liquid Combined with Rapid Heating Ways
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Catalytic synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones was efficiently promoted by as little as 2.5?mol% of Br?nsted acidic ionic liquid [(CH2)3SO3HMIM]HSO4 catalyst loading via rapid heating ways. Inter
- Zhang, Guo-Ping,Tian, Da-Yu,Shi, Wang-Ming
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p. 2522 - 2531
(2018/09/29)
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- T3P-DMSO mediated one-pot tandem approach for the synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones from alcohols
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Background: Biginelli reaction is one of the most important multiple-component chemical reactions which creates 3,4-dihydropyrimidin-2(1H)-ones. Even though Biginelli reaction was reported over a century using different substrates, literature lacks the ex
- Vinaya, Kambappa,Shivaramu, Prasanna D.,Chandrashekara, Ganganahalli K.,Chandrappa, Siddappa,Rangappa, Kanchugarakoppal S.
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p. 241 - 245
(2018/04/20)
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- A highly efficient and green catalytic synthesis of 3,4-dihydro-pyrimidin-2-(1H)-ones (thiones) using 3-sulfonic acid-1-imidazolopyridinium hydrogen sulfate under solvent-free conditions
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The ionic liquid catalyst 3-sulfonic acid-1-imidazolopyridinium hydrogen sulfate, [Simp]HSO4 was found to be a highly active and green catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones) under the solvent-free conditions. Av
- Bakherad, Mohammad,Javanmardi, Mohaddeseh,Doosti, Raheleh,Tayebee, Reza
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- Punica granatum peel: an organocatalyst for green and rapid synthesis of 3,4-dihydropyrimidin-2 (1H)-ones/thiones under solvent-free condition
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A novel and green approach was adopted for the synthesis of 3,4-dihydropyrimidin-2(1H)-one/thiones derivatives using Punica granatum peel as an inexpensive, efficient and mild catalyst under solvent-free condition. The methodology is characterized by high
- Mohammadian, Narges,Akhlaghinia, Batool
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p. 3325 - 3347
(2017/04/21)
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- 1-Methyl-2-oxopyrrolidinium perchlorate ionic liquid in synthesis of 5-ethoxycarbonyl-3,4-dihydropyrimidin-2(1H)-ones
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A multicomponent Biginelli reaction in a solvent-free conditions catalyzed by 1-methyl-2-oxopyrrolidinium perchlorate ionic liquid was studied. The сondensation of aromatic aldehydes, urea (thiourea), and acetoacetic ester yielded substituted 5-ethoxycarb
- Badalova,Abbasov,Valiyev,Alieva,Talybov
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p. 2739 - 2743
(2017/12/26)
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- A reactant promoted solvent free synthesis of 3,4-dihydropyrimidin-2(1H)-thione analogues using ammonium thiocyanate
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This is the first-time ammonium thiocyanate (NH4SCN) has been used as a self-promoting reactant for the synthesis of 3,4-dihydropyrimidin-2(1H)-thiones. This report describes a greener, efficient and economic protocol for one pot three-component synthesis of Biginelli compounds using various aldehydes, β-ketoesters and ammonium thiocyanate. Ammonium thiocyanate being a weak acid, accelerate the rate of reaction to obtain Biginelli compounds in solvent-free condition at 110?°C. The key advantages of the present method are high yields, short reaction time, solvent free condition, easy workup and ability to tolerate a variety of functional groups. Ammonium thiocyanate is readily available, cheaper, safer and industrial acceptable material which gives economical as well as ecological rewards to the present method.
- Khatri, Chetan K.,Potadar, Santoshkumar M.,Chaturbhuj, Ganesh U.
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supporting information
p. 1778 - 1780
(2017/04/13)
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- 1,4-diazabicyclo[2.2.2]octanium diacetate: As a new, effective and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and-thiones
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In this study, a new, effective and environmentally benign procedure for the synthesis of dihydropyrimidinone and thione derivatives with various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the presence of 1,4-diazabicyclo[2.2.2]octanium diacetate as a novel acidic ionic liquid, in high yield and short reaction time is reported. This method provides several advantages such as easy work-up, green, environmental friendliness and fast reaction condition along with high yields.
- Fekri, Leila Zare,Movaghari, Mahsa
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p. 406 - 413
(2016/10/18)
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- Fe3O4@PEG-SO3H rod-like morphology along with the spherical nanoparticles: Novel green nanocomposite design, preparation, characterization and catalytic application
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The design and preparation of polyethylene glycol sulfonic acid surface coated magnetic nanoparticles (Fe3O4@PEG-SO3H) is described. The morphology of the prepared nanocomposite was rod-like along with spherical nanopartic
- Maleki, Ali,Zand, Pedram,Mohseni, Zahra
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p. 110928 - 110934
(2016/12/07)
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- Nano isopolyoxomolybdate catalyzed Biginelli reaction for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones under solvent-free conditions
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The Biginelli reaction of β-ketoesters with aryl aldehyde and urea or thiourea in the presence of a Keplerate type giant nanoporous isopolyoxomolybdate, (NH4)42[Mo72 VIMo60 VO372
- Nakhaei,Davoodnia,Yadegarian
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p. 2870 - 2876
(2017/03/22)
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- PEG-SANM nanocomposite: A new catalytic application towards clean and highly efficient Biginelli-like reaction under solvent-free conditions
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A series of pyrimidinone derivatives were efficiently synthesized using PEG-SANM nanocomposite as the solid acid nanocatalyst under mild and solvent-free conditions. The generality of the process was successfully demonstrated by variation of the starting
- Dalil Heirati, Seyedeh Zahra,Shirini, Farhad,Shojaei, Abdollah Fallah
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p. 67072 - 67085
(2016/07/30)
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- 1,3-Disulfonic acid benzimidazolium chloride as an efficient and recyclable ionic liquid catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones
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1,3-Disulfonic acid benzimidazolium chloride ionic liquid ([Dsbim]Cl) was prepared, characterized and applied as an efficient, homogeneous and recyclable catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones through the one-pot three-com
- Abbasi, Mohsen
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p. 3303 - 3314
(2016/04/05)
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- Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction
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In this report, an efficient high-yield method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli reaction with various aldehydes, β-ketoesters/β-diketones and urea/thiourea is described. The reaction was catalyze
- Khatri, Chetan K.,Rekunge, Deelip S.,Chaturbhuj, Ganesh U.
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supporting information
p. 10412 - 10417
(2016/12/07)
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- A unique opportunity for the utilization of glass wastes as a resource for catalytic applications: toward a cleaner environment
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Although glass recycling has been conducted since 1970s, and even though recycled glass waste has been used in the construction of various alternative products, the utilization of glass waste for catalytic applications has not been fully considered until
- Zolfagharinia, Somayeh,Koukabi, Nadiya,Kolvari, Eskandar
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p. 113844 - 113858
(2016/12/24)
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- Saccharin: a green, economical and efficient catalyst for the one-pot, multi-component synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole
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Abstract: In this method, we have reported the catalytic ability of saccharin as a green, eco-friendly catalyst for the multi-component efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b]phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole with excellent yields and short reaction times. This present methodology has notable benefits such as green, inexpensive and non-toxic catalyst, one-pot, environmental benign nature, solvent-free conditions, simplicity of operation with no necessity of chromatographic purification steps and eco-friendly. Graphical Abstract: We have studied the catalytic ability of saccharin as a green, economical and environmentally benign nature for the multi-component efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-ones derivatives, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole with excellent yields and short reaction times. Green catalyst, mild, non-toxic, inexpensive, simple operational procedures, one-pot, high catalytic activity, eco-friendly, easily separated from the reaction mixture with no column chromatographic for the one-pot multi-component synthesis of these compounds are the most important advantages of this procedure.[Figure not available: see fulltext.]
- Mohamadpour, Farzaneh,Maghsoodlou, Malek Taher,Heydari, Reza,Lashkari, Mojtaba
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p. 1549 - 1560
(2016/07/06)
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- Natural organic acids promoted synthesis of 3, 4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions
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Naturally occurring organic acids are reported to be highly efficient promoters for the Biginelli reaction under thermal and microwave irradiation using solvent free conditions. Among the various organic acids used, malic acid was found to be the most eff
- Thorat, Nitin M.,Thopate, Shankar R.
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p. 210 - 216
(2015/06/23)
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- Efficient and Green Microwave-Assisted Multicomponent Biginelli Reaction for the Synthesis of Dihydropyrimidinones Catalyzed by Heteropolyanion-Based Ionic Liquids under Solvent-Free Conditions
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An efficient and green route for the synthesis of dihydropyrimidinones via microwave-assisted Biginelli reaction catalyzed by 3 mol% of heteropolyanion-based ionic liquids under solvent-free conditions has been reported. The practical reaction was found t
- Fu, Renzhong,Yang, Yang,Lai, Wenchen,Ma, Yongfeng,Chen, Zhikai,Zhou, Jian,Chai, Wen,Wang, Quan,Yuan, Rongxin
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supporting information
p. 477 - 487
(2015/10/29)
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- ZnO Nanoparticles as an Efficient, Heterogeneous, Reusable, and Ecofriendly Catalyst for One-Pot, Three-Component Synthesis of 3,4-Dihydropyrimidin-2(1 H)-(thio)one Derivatives in Water
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An extremely efficient heterogeneous protocol is reported for the one-pot, three-component synthesis of a series of dihydropyrimidinones (DHPMs) in the presence of ZnO nanoparticles in water as a green solvent. The ZnO nanoparticles exhibited excellent ca
- Hassanpour, Akbar,Khanmiri, Rahim Hosseinzadeh,Abolhasani, Jafar
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supporting information
p. 737 - 743
(2015/10/29)
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- Immobilization of phosphomolybdic acid nanoparticles on imidazole functionalized Fe3O4@SiO2: A novel and reusable nanocatalyst for one-pot synthesis of Biginelli-type 3,4-dihydro-pyrimidine-2-(1H)-ones/thiones under solven
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This article introduces Fe3O4@SiO2-imid-H3PMo12O40 nanoparticles as heterogenic catalyst for the synthesis of 3,4-dihydropyrimidinones under solvent-free condition. This reaction proceeds t
- Javidi, Jaber,Esmaeilpour, Mohsen,Dodeji, Fatemeh Nowroozi
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p. 308 - 315
(2015/02/03)
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- β-Cyclodextrin-propyl sulfonic acid: A new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidones via Biginelli reaction
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β-Cyclodextrin-propyl sulfonic acid (β-CD-PSA) is reported as a new and eco-friendly catalyst for the synthesis of 3,4-dihydropyrimidinones from one-pot multi-component reaction of aromatic aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under so
- Gong, Kai,Wang, Hualan,Wang, Shuxin,Ren, Xiaoxue
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p. 4830 - 4834
(2015/07/27)
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- Ammonium acetate promoted rapid and efficient synthesis of γ-Benzopyranones and 3,4-dihydropyrimidin-2(1H)-ones/thiones under solventfree conditions: A parallel scrutiny of microwave irradiation versus conventional heating
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Simple and highly efficient approach for the synthesis of γ-Benzopyranones and 3,4-Dihydropyrimidin-2(1H)-ones/thiones using ammonium acetate as a promoter under thermal as well as microwave irradiation using solvent-free conditions has been demonstrated.
- Thorat, Nitin M.,Dengale, Rohit A.,Thopate, Shankar R.,Rohokale, Sandeep V.
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p. 574 - 583
(2015/10/05)
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- Keggin type phosphotungstic acid encapsulated chromium (III) terephthalate metal organic framework as active catalyst for Biginelli condensation
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Keggin-type phosphotungstic acid (H3PW12O40, PTA) encapsulated in the mesocages of chromium-based terephthalate metal-organic framework (MIL-101) was established to be an active heterogeneous catalyst for three component B
- Saikia, Mrinal,Bhuyan, Diganta,Saikia, Lakshi
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p. 501 - 506
(2015/10/28)
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- General solvent-free ionic liquid catalyzed C-N/C-C coupled cyclization to diverse dihydropyrimidinones and new organic materials: Langmuir-Blodgett film study
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An ionic liquid catalyzed dual C-N/C-C coupled cyclization of a three component assembly is demonstrated to access 3,4-dihydropyrimidin-2(1H)-one (DHPM) analogues under solvent-free green conditions. Innovative new organic materials are introduced with pu
- Majumdar, Swapan,De, Jhinuk,Pal, Ajitesh,Ghosh, Indra,Nath, Ranendu K.,Chowdhury, Sandip,Roy, Dipanwita,Maiti, Dilip K.
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p. 24681 - 24686
(2015/03/30)
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- Synthesis of 1-alkyl triazolium triflate room temperature ionic liquids and their catalytic studies in multi-component Biginelli reaction
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Synthesis of three Brnsted acid-based ionic liquids, namely, 1-ethyl-1,2,4-triazolium triflate (1a), 1-propyl-1,2,4-triazolium triflate (1b) and 1-butyl-1,2,4-triazolium triflate (1c), is described. These ionic liquids have been employed as catalysts for
- Nagarajan, Sankaranarayanan,Shaikh, Tanveer M.,Kandasamy, Elango
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p. 1539 - 1545
(2015/12/01)
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- Solvent-Free Ball-Milling Biginelli Reaction by Subcomponent Synthesis
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We report here an understanding of systems chemistry on small molecules through covalent mechanochemistry. As a proof-of-concept, the multicomponent Biginelli reaction by subcomponent synthesis was considered as a model system. Reactions were performed un
- Sahoo, Prasit Kumar,Bose, Anima,Mal, Prasenjit
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supporting information
p. 6994 - 6998
(2015/11/16)
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- One-pot and green procedure for the synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)ones using ZnO nanoparticles as a solid acid catalyst
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A convenient and efficient method has been developed for the one-pot synthesis of dihydropyrimidinones (DHPMs) compounds. Dihydropyrimidinone derivatives were synthesized in good yields using ethyl acetoacetate, aldehyde (aromatic and aliphatic) and urea
- Hassanpour, Akbar,Abolhasani, Jafar,Khanmiri, Rahim Hosseinzadeh
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p. 445 - 449
(2015/05/13)
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- Highly efficient and magnetically recoverable niobium nanocatalyst for the multicomponent biginelli reaction
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A new magnetically recoverable nanocatalyst was prepared by coating magnetite with niobium oxide (Fe3O4@Nb2O5) by using a simple wet impregnation method. The Fe3O4@Nb2O5/su
- Lima, Carolina G. S.,Silva, Sandrina,Gonalves, Ricardo H.,Leite, Edson R.,Schwab, Ricardo S.,Corra, Arlene G.,Paixo, Mrcio W.
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p. 3455 - 3463
(2015/04/16)
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- One-pot and solvent-free synthesis of 1,4-dihydropyridines and 3,4-dihydropyrimidine-2-ones using new synthetic recyclable catalyst via Biginelli and Hantzsch reactions
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Pyridine dicarboxylic acid guanidine-cobalt complex (PDAG-Co) (3) catalyzes one-pot, three-component coupling of aldehydes, b-dicarbonyl compounds, and ammonium acetate to afford the corresponding 1,4-dihydropyridines (1,4-DHPs) via Hantzsch reaction. 3,4
- Shockravi, Abbas,Kamali, Mahmood,Sharifi, Negar,Nategholeslam, Mahdieh,Moghanlo, Somayeh Pahlavan
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supporting information
p. 1477 - 1483
(2013/05/21)
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- Vanadatesulfuric acid: A novel, recyclable, and heterogeneous catalyst for the one-pot synthesis of dihydropyrimidinones and dihydropyrimidinthiones under solvent-free conditions
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Vanadatesulfuric acid (VSA), as a novel and heterogeneous catalyst, was used for an efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones) using an aldehyde, urea, or thiourea and an acyclic β-dicarbonyl compound under solvent-free conditions. V
- Nasr-Esfahani, Masoud,Abdizadeh, Tooba
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p. 596 - 608
(2013/07/25)
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- A green recyclable poly(4-vinylpyridine)-supported copper iodide nanoparticles catalyst for the multicomponent synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones
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Dihydropyrimidone derivatives are important class of compounds that received significant attention from many pharmaceutical and organic chemists because of the broad spectrum of their biological and pharmaceutical properties such as antibacterial, anti-in
- Albadi, Jalal,Mansournezhad, Azam,Baghernehad, Mojtba,Frozan, Nasrin
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p. 169 - 171
(2013/07/25)
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- Silica gel supported bismuth nitrate pentahydrate: A highly active catalyst under solvent free conditions towards the synthesis of dihydropyrimidin-2(1H)- ones and their sulphur analogues
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Silica gel supported bismuth nitrate pentahydrate has been shown to be an efficient catalyst for the Biginelli reaction. The main advantages of the catalyst include short reaction time and high yield of the products. This observation has been confirmed by
- Hingane, Dattatray G.,Shumaila, Abdullah M.A.,Kusurkar, Radhika S.
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p. 1161 - 1165
(2013/09/24)
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- One-pot, green and efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones or thiones catalyzed by citric acid
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One-pot three-component condensation of ethyl acetoacetate, aldehyde and urea or thiourea in refluxing ethanol in the presence of catalytic amounts of citric acid afforded the corresponding 3,4-dihydropyrimidin- 2(1H)-ones/thiones in high yields. The cata
- Ghorbani-Choghamarani, Arash,Taghipour, Tahereh,Azadi, Gouhar
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p. 1202 - 1206
(2014/04/03)
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- A novel amino acid functionalized ionic liquid promoted one-pot solvent-free synthesis of 3,4-dihydropyrimidin-2-(1H)-thiones
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An environmentally benign, cheap and reusable L-amino acid functionalized ionic liquid [L-AAIL]/AlCl3 was found to be an effective catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-thione derivatives in good to excellent yield under so
- Karthikeyan, Parasuraman,Kumar, Sythana Suresh,Arunrao, Aswar Sachin,Narayan, Muskawar Prashant,Bhagat, Pundlik Rambhau
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p. 1335 - 1342
(2013/06/05)
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- DABCO as a mild and efficient catalyst for the synthesis of tetrahydropyrimidines
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Tetrahydropyrimidine derivatives have been synthesized in good to high yields through an efficient and one-pot condensation reaction of aldehydes, ethyl acetoacetate and urea (thiourea) using 1,4-diazabicyclo[2.2.2]octane (DABCO) as an inexpensive, eco-fr
- Foroughifar, Naser,Mobinikhaledi, Akbar,Rabeie, Bahare,Jalili, Leila
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p. 491 - 495
(2014/04/03)
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- A green synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives using nanosilica-supported tin(II) chloride as a heterogeneous nanocatalyst
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Efficient, green, and straightforward synthesis of 3,4-dihydropyrimidine- 2(1H)-one/thione derivatives under favorable conditions has been achieved by reaction of urea/thiourea, aldehydes, and ethyl acetoacetate, using the synthetic potential of nanosilic
- Safaei Ghomi, Javad,Teymuri, Raheleh,Ziarati, Abolfazl
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p. 1865 - 1870
(2014/01/06)
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