- Alternative synthesis of the anti-baldness compound RU58841
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RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete inert atmosphere steps and three steps that require flash chromatography. Our synthesis uses no phosgene, only one inert atmosphere step and does not require flash chromatography. This is achieved by stepwise construction of the hydantoin moiety around the amino group of 3-trifluoromethyl-4-cyanoaniline and ring closure to give a 2-nitropropane leaving group. On a small scale we achieved an overall yield of 33%.
- Leonard, Matthew J.,Lingham, Anthony R.,Niere, Julie O.,Jackson, Neale R. C.,McKay, Peter G.,Huegel, Helmut M.
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p. 14143 - 14148
(2014/04/17)
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- Cosmetic or pharmaceutical compositions
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A cosmetic or pharmaceutical composition containing a dermatologically effective amount of at least one liposome containing a compound of the formula
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- Phenylimidazolidine preparation process
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A subject of the invention is a preparation process for the products of formula (I): STR1 in which R1 and R2 represent in particular hydrogen, cyano, halogen or amino,R3 represents in particular hydrogen or hydroxyl alkyl, R4 and R5 represent in particular optionally substituted alkyl, X and y represent oxygen or sulphur, characterized in that a product of formula (A): STR2 is prepared in which W represents a halogen atom or a hydantoin derivative, which is subjected to various reactions in order to obtain the products of formula (I), all their isomers and their salts.
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