- Synthesis, conformation and biological properties of selenonucleosides
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Synthesis, conformation and antitumour properties of novel 2- and 4- selenopyrimidine nucleosides are described.
- Felczak, Krzysztof,Miazga, Agnieszka,Golos, Barbara,Rode, Wojciech,Shugar, David,Kulikowski, Tadeusz
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- ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
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The present invention relates to isoxazolidines of formula I and their use as receptor-interacting protein kinase 1 inhibitors, for example in the treatment of diseases and disorders mediated by RIP kinase (1) such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease (IBD), Crohn's disease or ulcerative colitis.
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Page/Page column 167
(2021/12/31)
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- Flucytosine preparation method applicable to industrial production
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The invention discloses a flucytosine preparation method applicable to industrial production. The method comprises the following steps: performing chlorination on fluorouracil, performing ammonification, and performing hydrolysis, thereby obtaining flucytosine. To solve defects, the invention provides the flucytosine preparation method applicable to industrial production, and the method is small in process procedure, simple in operation, low in investment cost, relatively good in prospect and applicable to large-scale industrial production.
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Paragraph 0013
(2017/08/27)
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- SYNTHESIS AND AMINATION OF 2,4-DICHLORO-5-FLUOROPYRIMIDINE
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2,4-Dichloro-5-fluoropyrimidine was prepared by the chlorination of 5-fluorouracil with phosphorus pentachloride in absence of solvent.The reaction of 2,4-dichloro-5-pyrimidine with primary and secondary aliphatic and heteroaromatic amines in an aqueous medium yields 2-chloro-4-RR'-amino-5-fluoropyrimidines, with stereoselective substitution of chlorine in the C4 position.The substances obtained have well-defined fungicidal activity.
- Kovalenko, A. L.,Krutikov, V. I.,Zolotukhina, M. M.,Alekseeva, L. E.
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p. 1122 - 1125
(2007/10/02)
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