- Sustainable Cascades to Difluoroalkylated Polycyclic Imidazoles
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We reported herein a visible light promoted difluoroalkylated cascade of imidazoles and alkenes to afford highly functionalized polycyclic imidazoles. This method features a direct radical cyclization of imidazoles with alkenes using BrCF2R as radical sources. The reaction conditions tolerate a wide range of substrate scope and afford the desired products with up to 95 % isolated yield under mild conditions. Radical-trapping and light-on/off experiments indicated a photocatalytic radical mechanism.
- Lin, Sheng-Nan,Chen, Yu,Luo, Xiao-Dong,Li, Yi
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- Synthesis of 4,4-Difluoroalkenes by Coupling of α-Substituted α,α-Difluoromethyl Halides with Allyl Sulfones under Photoredox Catalyzed Conditions
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Photoredox-catalyzed allylation of α-gem-difluorinated organohalides with allyl sulfones proceeded smoothly under visible light irradiation to give 4,4-difluoroalkenes in good yields. In the presence of catalytic Ru(bpy)3Cl2, Hantzsch ester, and diisopropylethylamine, the reaction was complete within 2 h. Using the same methodology, three-component cascade reactions to give 6,6-difluoroalkenes were carried out successfully.
- Uno, Misae,Sumino, Shuhei,Fukuyama, Takahide,Matsuura, Makoto,Kuroki, Yoshichika,Kishikawa, Yosuke,Ryu, Ilhyong
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p. 9330 - 9338
(2019/08/12)
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- NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS
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The present invention relates to compound of formula (I) and their use for treating bacterial infections.
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Page/Page column 32
(2018/08/26)
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- NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS
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The present invention relates to compound of formula (I) and their use for treating bacterial infections
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Paragraph 0139; 0140
(2018/08/20)
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- Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination
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The nucleophilic fluorination of bromodifluoromethyl derivatives mediated by the complex (PPh3)3CuF is described. Under the reaction conditions, different trifluoroacetates, trifluoroketones, trifluoroarenes and trifluoroacetamides were obtained in good yields.
- Bermejo Góme, Antonio,González, Miguel A. Cortés,Lübcke, Marvin,Johansson, Magnus J.,Schou, Magnus,Szabó, Kálmán J.
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- Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides
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Nucleophilic 18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.
- Gómez, Antonio Bermejo,Cortés González, Miguel A.,Lübcke, Marvin,Johansson, Magnus J.,Halldin, Christer,Szabó, Kálmán J.,Schou, Magnus
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supporting information
p. 13963 - 13966
(2016/12/09)
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- POLYMERIZABLE COMPOUND HAVING ALKALI-DISSOCIABLE GROUP
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PROBLEM TO BE SOLVED: To provide (meth) acrylic acid ester useful as immersion exposure resist. SOLUTION: This invention relates to (meth) acrylic acid ester represented by the formula (m-1-1a) and having alkali-dissociable group, where R8 is C1-10 fluorine substituted hydrocarbon group; Rf is F or C1-10 perfluoroalkyl group; n1 is an integer of 0-4; R2 is single bond, methylene group or the like; R31 is methylene group or the like; and R is H, methyl group or the like. COPYRIGHT: (C)2015,JPO&INPIT
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Paragraph 0208-0210
(2017/01/02)
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- COMPOUNDS
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The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.
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Page/Page column 37
(2014/02/16)
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- 2-SACCHARINYLMETHYL ARYL CARBOXYLATES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND COMPOSITIONS AND METHOD OF USE THEREOF
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A compound having the formula: STR1 wherein Ar, R 4 and R 5 are defined herein have pharmaceutical utility as proteolytic enzyme inhibitors.
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- Novel Synthesis of 2,2,2-Trifluoroethyl Compounds from Homoallylic Alcohols: A Copper(I) Iodide-initiated Trifluoromethyl-Dehydroxylation Process
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Benzyl, prop-2-enyl and allyl chlorodifluoroacetates 3a, bromodifluoroacetates 3b or fluorosulfonyldifluoroacetates 3c, when decomposed in the presence of 1 equivalent of copper(I) iodide at an appropriate temperature in dimethylformamide, gave the corresponding trifluoromethyl derivatives in good to excellent yields.The products can also be obtained directly by ester exchange of XCF2CO2Et (X = FSO2, Cl, Br) 6 and the corresponding alcohols in the presence of KF and CuI.A trifluoromethylation-dehydroxylation mechanism, initiated by CuI, is proposed.
- Duan, Jian-Xing,Chen, Quing-Yun
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p. 725 - 730
(2007/10/02)
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