- Palladium-catalyzed base-selective H-D exchange reaction of nucleosides in deuterium oxide
-
We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H2 system into the base moiety of nucleosides. The results presented here provide a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D 2O media. Georg Thieme Verlag Stuttgart.
- Sajiki, Hironao,Esaki, Hiroyoshi,Aoki, Fumiyo,Maegawa, Tomohiro,Hirota, Kosaku
-
-
Read Online
- Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides
-
The efficient synthesis of the highly-deuterated thymidine-d9 by the glycosylation reaction between a deuterated nucleobase and deuterated sugar is described. It is also incorporated into the oligonucleotides using a DNA synthesizer. Using this
- Taniguchi, Yosuke,Cao, Xiuming,Sasaki, Shigeki
-
-
- Diphenylamino pyrimidine compound for inhibiting kinase activity
-
The invention provides a diphenylamino pyrimidine compound for inhibiting the kinase activity, and particularly provides a medicinal composition of a substituted diphenylamino pyrimidine compound andapplication thereof. The compound is a compound as shown in a formula (I) in the specification, or pharmaceutically acceptable salt, prodrug, hydrate thereof or solvent compound, crystal form, N-oxideand various diastereomers thereof. The compound can be used for treating diseases which can be treated with JAK2 kinase inhibitors.
- -
-
Paragraph 0150; 0151; 0152; 0153; 0154; 0155
(2019/02/04)
-
- METHOD FOR DEUTERATION OR TRITIATION OF HETEROCYCLIC RING
-
The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.
- -
-
Page/Page column 16
(2008/06/13)
-
- Synthesis of base-selectively deuterium-labelled nucleosides by the Pd/C-catalyzed H-D exchange reaction in deuterium oxide
-
The D2 gas-free and base-selective H-D exchange reaction of nucleosides was developed. It discloses a convenient route to the post-synthetic incorporation of deuteriums into the base moiety of nucleic acids with high deuterium efficiency.
- Esaki, Hiroyoshi,Aoki, Fumiyo,Maegawa, Tomohiro,Hirota, Kosaku,Sajiki, Hironao
-
p. 361 - 369
(2007/10/03)
-