- COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME
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Disclosed are compounds of general formula (I) that promote readthrough of a premature termination codon (PTC) of an RNA molecule in a translation system, and their use, alone or in combination with other compounds, such as aminoglycoside, to treat diseases or disorders ameliorated by modulation of a premature termination codon (PTC) of an RNA molecule in a translation system. The disorder or disease may be Dystrophic epidermolysis bullosa, Batten disease, Duchenne muscular dystrophy, cancer, and spinal muscular atrophy. Ar-L-B (I)
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Page/Page column 213; 214; 215; 216; 217; 218
(2017/04/11)
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- Imidazole derivatives as PDE10A enzyme inhibitors
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This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The pr
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Page/Page column 9
(2012/06/01)
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- Benzodiazepines and isoindoles by acylation of amidines
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The reaction of amidines with difunctional electrophiles represents a simple access to N-heterocycles as anellated 2,4-benzodiazepines and isoindoles. A new model to describe the reactivity of molecules quantitatively has been elaborated and used to explain the formation of the heterocyclic products.
- Lessel
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p. 812 - 816
(2007/10/02)
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