A general approach for the synthesis of phenolic natural products. Facile syntheses of grifolin and colletochlorins B and D
A general approach is established for the synthesis of phenolic compounds having terpenoid side chains: (1) protection of the phenolic hydroxyls in the aromatic precursor by ether formation, (2) coupling the aromatic part with a terpenoid bromide, and (3) deprotection to regenerate the hydroxyl groups. This strategy was successfully applied to the synthesis of colletochlorins B and D and grifolin. Some of the colletochlorin derivatives were found to inhibit the cell growth of P388.
Saimoto,Ueda,Sashiwa,Shigemasa,Hiyama
p. 1178 - 1185
(2007/10/02)
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