2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors
2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochemical properties.
Costales, Abran,Mathur, Michelle,Ramurthy, Savithri,Lan, Jiong,Subramanian, Sharadha,Jain, Rama,Atallah, Gordana,Setti, Lina,Lindvall, Mika,Appleton, Brent A.,Ornelas, Elizabeth,Feucht, Paul,Warne, Bob,Doyle, Laura,Basham, Stephen E.,Aronchik, Ida,Jefferson, Anne B.,Shafer, Cynthia M.
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p. 1592 - 1596
(2014/03/21)
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