- Pepstatin A derivatives
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The invention relates to a compound having a structure according to the general formula P3-P2-P1-P1'-P2' (I), wherein residues P3, P2, P1, P1' and P2' are specifically defined and may be, e. g., certain amino acid residues. The invention further relates to the use of said compound and to a method for synthesizing a peptide.
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- Total synthesis of miraziridine A and identification of its major reaction site for cathepsin B
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The synthesis of miraziridine A, a pentapeptide derivative isolated from marine sponge, and its truncated analogs has been achieved. To construct the backbone of miraziridine A, a side-chain-unprotected vinylogous arginine was condensed with an aziridine-
- Konno, Hiroyuki,Kubo, Kanako,Makabe, Hidefumi,Toshiro, Emi,Hinoda, Naoyuki,Nosaka, Kazuto,Akaji, Kenichi
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p. 9502 - 9513
(2008/02/12)
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- Synthesis of Chiral Urethane N-Alkoxycarbonyl Tetramic Acids from Urethane N-Carboxyanhydrides (UNCAs)
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The synthesis of chiral N-protected tetramic acid derivatives which are precursors of β-hydroxy γ-amino acid under mild conditions is described.Reaction of urethane-N-carboxyanhydrides (UNCAs) with Meldrum's acid in the presence of a tertiary amine, follo
- Fehrentz, Jean-Alain,Bourdel, Elisabeth,Califano, Jean-Christophe,Chaloin, Oliveir,Devin, Chantal,et al.
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p. 1557 - 1560
(2007/10/02)
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