- Unsymmetrical Naphthyridine-Based Dicopper(I) Complexes: Synthesis, Stability, and Carbon-Hydrogen Bond Activations
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Two unsymmetrical dinucleating naphthyridine-based ligands with di(pyridyl) and phosphino side arms were employed in the synthesis of dicopper(I) chloride cores that activate NaBPh4to afford bridging phenyl organocopper complexes. In these compounds, the bridging ligand binds symmetrically, as observed in previously described symmetrical dicopper(I) complexes supported by naphthyridine-based ligands with two di(pyridyl) side arms. Unlike the symmetrical systems, however, these complexes undergo quasireversible electrochemical reductions, and chemical reduction yields a diamagnetic product resulting from the coupling of naphthyridine-based radicals of two complexes. The μ-Ph complexes activate the C-H bonds of terminal alkynes and the electron-poor arene C6F5H. By DFT calculations, the mechanism of terminal alkyne activation involves H-atom transfer at the cationic dicopper center and is sensitive to subtle changes in copper-ligand interactions as well as the position of the anion.
- Balcells, David,Héron, Julie,Kuramarohit, Serene,Nicolay, Amélie,Shin, Chungkeun,Tilley, T. Don,Ziegler, Micah S.
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- Naphthyridine-based iridium complexes: Structures and catalytic activity on alkylation of aryl ketones
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Iridium(III) complexes containing a designed ligand, 2-amino-7-(2-pyridinyl)-1,8-naphthyridine derivative, were prepared and all complexes were characterized using spectroscopic and crystallographic methods. These new Ir(III) complexes are able to act as catalysts for the C-alkylation of aryl alkyl ketones with the use of alcohols as the alkylating agent. Typically, acetophenone undergoes alkylation with methanol and ethanol to yield isobutyrophenone and butyrophenone, respectively.
- Chen, Po-Hao,Liu, Yi-Hung,Liu, Shiuh-Tzung
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p. 972 - 981
(2019/05/24)
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- Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives
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We report that a polyhedral oligomeric silsesquioxane (POSS) core in a dendrimer can enhance the affinity of the molecular recognition via hydrogen bonds between 1,8-naphthyridine and guanosine nucleotides. The complexation of the naphthyridine ligands with a series of guanosine nucleotides was investigated, and it is shown that the POSS core should play a significant role in the stabilization of the complexes via hydrogen bonds. Finally, we demonstrate that the 1,8-naphthyridine ligand can selectively recognize guanosine triphosphate by assisting with the POSS-core dendrimer.
- Tanaka, Kazuo,Murakami, Masahiro,Jeon, Jong-Hwan,Chujo, Yoshiki
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experimental part
p. 90 - 95
(2012/01/11)
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- Simple and efficient synthesis of 2,7-difunctionalized-1,8-naphthyridines
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The syntheses in good yields of some new difunctionalized 1,8-naphthyridines 4, 6, 8 and 9 and a novel triethylene glycol ether-linked dinaphthyridine, 10a, along with the mononaphthyridine-linked ether alcohol 10b are described. An improved and milder method for the synthesis of 2,7-diamino-1,8-naphthyridine (14) is also reported.
- Goswami, Shyamaprosad,Mukherjee, Reshmi,Mukherjee, Rakhi,Jana, Subrata,Maity, Annada C.,Adak, Avijit Kumar
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p. 929 - 936
(2007/10/03)
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