cas 159974-55-7, TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER | Articles data ｜lookchem

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159974-55-7

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AROMATIC AMIDES
This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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(2008/06/13)

Use of 2-Oxazolidinones As Latent Aziridine Equivalents. III. Preparation of N-Substituted Piperazines.
A number of N-aryl and N-alkyl substituted piperazines 1 were prepared from variously substituted 2-oxazolidinone derivatives 3.The method involved treatment of 3 with HBr in glacial acetic acid followed by heating the resulting ring-opened salts 5 in alcoholic solvent.The piperazines 1a-1q were isolated by crystallization in yields ranging from 23-91percent.
Poindexter, Graham S.,Bruce, Marc A.,LeBoulluec, Karen L.,Monkovic, Ivo
p. 7331 - 7334
(2007/10/02)

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Chemical Properties

Melting Point: 68-69°
Boiling Point: 528.7±33.0 °C(Predicted)
Density: 1.335±0.06 g/cm3(Predicted)
PKA: -1.61±0.20(Predicted)
PSA: 81.29000
LogP: 2.17120

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