- Small structure tree alkali compound and its preparation method and application
-
The invention relates to a Broussonetia kazinoki alkaline compound. Structure of the compound is shown as a formula (1). The invention further provides a preparation method of the compound, a glycosidase inhibitor by using the compound or the compound prepared by the method as an active ingredient and application of the compound or the compound, prepared by the method, serving as an active ingredient in preparing drug. The Broussonetia kazinoki alkaline compound has high glycosidase inhibiting activity and potential medicinal value.
- -
-
-
- Small structure tree alkali compound and its preparation method and application
-
The invention relates to a Broussonetia kazinoki alkaline compound. Structure of the compound is shown as a formula (1). The invention further provides a preparation method of the compound, a glycosidase inhibitor by using the compound or the compound prepared by the method as an active ingredient and application of the compound or the compound, prepared by the method, serving as an active ingredient in preparing drug. The Broussonetia kazinoki alkaline compound has high glycosidase inhibiting activity and potential medicinal value.
- -
-
-
- Polyhydroxylated pyrrolidine compound as well as preparation method and application thereof
-
The invention relates to the field of glycosidase inhibitors and particularly relates to a polyhydroxylated pyrrolidine compound as well as a preparation method and application thereof. The structure of the polyhydroxylated pyrrolidine compound is as shown in formula (I). The polyhydroxylated pyrrolidine compound has high glycosidase inhibition activity and has a potential medicinal value. The formula is as shown in description.
- -
-
-
- List fluoro Radicamine compounds and their use and preparation method
-
The invention discloses a mono-fluorinated Radicamine compound which has a structure as shown in a formula (1), and further provides a preparation method for the mono-fluorinated Radicamine compound with the structure as shown in the formula (1) and an application of the mono-fluorinated Radicamine compound or the mono-fluorinated Radicamine compound prepared with the method to preparation of drugs for preventing and/or treating diabetes, drugs for preventing and/or treating Gaucher's diseases, drugs for preventing and/or treating tumors or antiviral drugs. The mono-fluorinated Radicamine compound provided by the invention is good in glycosidase inhibition activity.
- -
-
-
- Chemical Synthesis of Ketopentose-5-phosphates
-
A chemical synthesis of ketopentose-5-phosphates that are involved in the pentose phosphate pathway has been developed. The ketopentose phosphates, d-ribulose-5-phosphate and d-xylulose-5-phosphate, were prepared in five steps starting from known intermed
- Wei, Wei-Chih,Chang, Che-Chien
-
p. 3033 - 3040
(2017/06/20)
-
- β-D-Arabinosyl 1- C -sulfonic acid
-
A short synthetic route to β,D-arabinofuranosyl 1-C-sulfonic acid (7), a possible biomimetic for the arabinofuranosyl anomeric phosphate, is described. The furanosyl 1-C-sulfonate was prepared by buffered dimethyldioxirane oxidation of an S-acetyl-1-thio-
- Won, Walter S.,Knapp, Spencer
-
-
- NEW PHOSPHORUS CONTAINING HETEROCYCLIC COMPOUNDS, SUGAR ANALOGUES, AND COMPOSITIONS HAVING ANTI-CANCER ACTIVITY CONTAINING THE SAME
-
The invention provides new anticancer compounds of formula (1) such as defined in the present description. The invention also provides pharmaceutical compositions to be used in human or veterinary medicine, comprising at least one compound of formula (1). The present invention further relates to a compound of formula (1) such as defined in the present description, for use as a drug. The invention further relates to the use of a compound of formula (1) for manufacturing a human or animal anticancer pharmaceutical composition.
- -
-
Page/Page column 35-36
(2009/03/07)
-
- Stereoselective synthesis of β-arabino glycosyl sulfones as potential inhibitors of mycobacterial cell wall biosynthesis
-
A series of β-arabino glycosyl sulfones with varying alkyl chain lengths were synthesised in a stereoselective fashion as putative mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Biological
- Ayers, Benjamin,Long, Hilary,Sim, Edith,Smellie, Iain A.,Wilkinson, Brendan L.,Fairbanks, Antony J.
-
scheme or table
p. 739 - 746
(2009/06/08)
-
- Synthesis of chiral carbohydrate ionic liquids
-
Chiral room temperature ionic liquids, containing a carbohydrate moiety linked at the anomeric centre to an N-methylimidazolium group have been synthesised. The ionic liquids were prepared in a concise manner and provided ready access to both the D- and L
- Plaza, Patrice G. J.,Bhongade, Bhoomendra A.,Singh, Gurdial
-
scheme or table
p. 2973 - 2976
(2009/06/27)
-
- Stereoselective synthesis of a ketohexofuranose from an aldohexopyranose by a [6+1-1] strategy
-
Ozonolysis of 2-acetoxymethyl-1,5-anhydro-3,4,6-tri-O-benzyl-2-deoxy-D- arabino-hex-1-enitol gave 1-O-acetyl-3,4,6-tri-O-benzyl-4-O-formyl-D-arabino- hex-2-ulose (5). Subsequent hydrolysis and acetylation of 5 provided 1,2-di-O-acetyl-3,4,6-tri-O-benzyl-D
- Babu, Boga Sobhana,Balasubramanian, Kalpattu Kuppuswamy
-
p. 753 - 758
(2007/10/03)
-
- Regioselectivity in Alkylation Reactions of 1,2-O-Stannylene Acetals of D-Arabinofuranose
-
The synthesis of β-arabinofuranosides via alkylation of 1,2-O-stannylene acetal intermediates has been studied. With reactive alkyl halides (benzyl bromide, allyl bromide, and p-methoxybenzyl chloride), the method provides a mixture of β-arabinofuranosides and 2-O-alkylated lactols in ratios of 4:1 to 1:1.5. However, with carbohydrate-derived electrophiles, no alkylated products are produced. It appears, therefore, that the method is limited to the preparation of β-arabinofuranosides of simple alcohols. Through the use of computational chemistry, we have explored the conformational properties of one of these stannylene acetals and propose that these species exist in more than one conformation in solution and that this contributes to the relatively poor regioselectivity in these reactions.
- Darwish, Omar S.,Callam, Christopher S.,Hadad, Christopher M.,Lowary, Todd L.
-
p. 963 - 981
(2007/10/03)
-
- Total syntheses of hyacinthacine A2 and 7-deoxycasuarine by cycloaddition to a carbohydrate derived nitrone
-
Practical syntheses of nitrone 8 by two different approaches from sugars are reported. Its use as a versatile intermediate in highly selective 1,3-dipolar cycloaddition reactions constitutes the key step for novel total syntheses of hyacinthacine A2
- Cardona, Francesca,Faggi, Enrico,Liguori, Francesca,Cacciarini, Martina,Goti, Andrea
-
p. 2315 - 2318
(2007/10/03)
-
- A study of Pd(II) Cl2/CuCl catalysed Wacker reaction for the deprotection of prop-2-enyl and prop-1-enyl ethers
-
Pd(II)Cl2 (1 mole equivalent)/CuCl/DMF-H2O/O2/2h catalysed oxidation of various prop-2-enyl ethers 1a-12a is reported to result in the formation of Wacker ketones 1b,3b,5b,6b,9b,11b,12b (12-51%), hydrolysis products 2c,4c-7c,9c-12c (12-43%) and η2-vinyl complexes of palladium chloride 2c,4c,7c,8c (52-94%) respectively. The corresponding prop-1-enyl ethers 2e,4e-12e under similar conditions react with a catalytic amount of Pd(II)Cl2 (0.2 mole equivalent) rapidly (15-20 min.) to give exclusively hydroxy compounds 2c,4c-12c respectively in good yields (75-97%).
- Mereyala, Hari Babu,Lingannagaru, Sarita Reddy
-
p. 17501 - 17512
(2007/10/03)
-
- A convenient synthesis of the five-membered lactams from D-arabinose
-
Synthesis of the five-membered lactams, (3S, 4R, 5S)-1-benzoyl-and (3S, 4R, 5S)-1-benzyloxycarbonyl-5-benzyloxymethyl-3, 4-dibenzyloxypyrrolidin-2-ones (3a and 3b) which are the important intermediates for the unsaturated five membered amino acid moiety (
- Konda, Yaeko,Machida, Tomomi,Akaiwa, Michiko,Takeda, Kazuyoshi,Harigaya, Yoshihiro
-
p. 555 - 565
(2007/10/03)
-
- C-glycofuranosides via tandem Wittig-Michael sequence using a thiazole-armed phosphorane. A route to C-furanosyl α-hydroxy propanals and propionic acids
-
The reactions of 2-thiazolylcarbonylmethylenetriphenylphosphorane with five protected D-furanoses (manno, ribo, arabino, xylo, and lyxo) in refluxing toluene lead to mixtures of α- and β-1-C-(2-thiazolacyl)-glycosides (66-93 % overall yield). The β-linked C-glycosides derived from 2,3:5,6-di-O-isopropylidene-D-mannnofuranose was reduced to (R) and (S) akohols which after protection as O-benzyl ethers were transformed to α-alkoxy aldehydes by thiazole-to-formyl conversion; the aldehydes were oxidized to the corresponding α-alkoxy acids.
- Dondoni, Alessandro,Marra, Alberto
-
p. 7327 - 7330
(2007/10/02)
-
- Synthesis of 2,3,5-tri-O-benzyl-D-arabinitol 1,4-cyclic sulfate and its conversion into potential precursors of shikimate substrate analogues
-
A practical route to deoxycarbohydrates, which may serve as starting materials in the synthesis of shikimate substrate analogues is described. The deoxy derivatives ethyl 4,5,7-tri-O-benzyl-3-deoxy-α-D-arabino-2-heptulopyranosonate (10), 3,4,6-tri-O-benzy
- Van der Klein,De Nooy,Van der Marel,Van Boom
-
p. 347 - 349
(2007/10/02)
-