cas 161005-84-1, (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1) | Articles data ｜lookchem

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161005-84-1

Articles about 161005-84-1Total 4 be found

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PREPARATION OF DULOXETINE AND ITS SALTS
The present patent application relates to a process for the preparation of Duloxetine and its salts comprising reacting (S) - (+)-N, N-Dimethyl-3-(2- thienyl)-3-hydroxypropanamine or a salt there of with 1-fluoronapthalene in the presence of sodium hydride and potassium 4-methyl benzoate; N- demethylation via formation of phenylcarbamate to obtain Duloxetine which may then converted in to a pharmaceutically acceptable salt.
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Page/Page column 10

(2009/12/05)

IMPROVED PROCESS FOR THE ASYMMETRIC SYNTHESIS OF DULOXETINE
This invention provides an improved asymmetric process for the synthesis of duloxetine involving arylation of Compounds of Formula I.
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Page/Page column 4

(2008/06/13)

Treatment of incontinence
Urinary incontinence in humans is treated by administration of venlafaxine or a compound chosen from a series of aryloxy propanamines.
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(2008/06/13)

Asymmetric synthesis
This invention provides a stereospecific process for the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a key intermediate in the synthesis of duloxetine.
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(2008/06/13)

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Chemical Properties

Storage Temp.:2-8°C
PSA: 128.28000
LogP: 4.04450

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