Enantioselective synthesis of α-branched α-hydroxy ketones via chiral N-sulfonyl-2-alkyl-2-cyano-1,3-oxazolidines
The stereochemically homogeneous title compounds 6, prepared with two steps from orthoesters and N-tosyl-phenylglycinol 4, afford with two sequential Grignard additions predominantly the tertiary alcohols 8. Electrochemical detosylation, followed by aqueo