- METHOD FOR THE SYNTHESIS OF HETEROCYCLIC HYDROGEN PHOSPHINE OXIDE
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The present invention is related to a method for the synthesis of a heterocyclic hydrogen phosphine oxide, having the general formula (I), wherein: - R is a aliphatic or aromatic divalent group optionally comprising one or more heteroatoms and optionally comprising one or more substituents and - X and Y are independently selected from -O-, -C(O)O- and -NR'- wherein R' is a monovalent group optionally comprising one or more heteroatoms comprising the steps of: a) forming a reaction mixture by mixing a compound having the general formula HX-R-YH and tetraphosphorus hexaoxide; b) recovering the resulting compound comprising the heterocyclic hydrogen phosphine oxide.
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Paragraph 0059
(2016/03/13)
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- New method of alkylene phosphonate preparation
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A new method of alkylene phosphonate preparation has been elaborated, based on the reaction of the corresponding cyclic ethers and phosphonic acid in the presence of acetic anhydride.
- Klosinski
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p. 2025 - 2028
(2007/10/02)
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- Stereochemistry of organophosphorus cyclic compounds. Part 5. Synthesis and geometry of some 4,5-disubstituted 1,3,2-dioxaphospholan-2-thiones and stereochemistry of nucleophilic displacement reactions at phosphorus
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Geometrical isomers of 2-hydroxy-4,5-dimethyl-1,3,2-dioxaphospholan-2-thione, 2-halogeno-4,5-dimethyl-1,3,2-dioxaphospholan-2-thione (X= Cl, Br, or F) and 2-hydroxy-4,5-diphenyl-1,3,2-dioxaphospholan-2-thione have been prepared in a stereospecific manner. Stereochemistries of these isomers are assigned on the basis of chemical correlations and n.m.r. measurements. 2-Chloro- and 2-bromo-4,5-dimethyl-1,3,2-dioxaphospholan-2-thione have been found to undergo methanolysis, aminolysis, and mercaptolysis with retention of configuration at phosphorus. Halogen-halogen exchange at the phosphorus atom is also described. The relationship between cis-and trans-geometry of disubstituted 1,3,2-dioxaphospholan-2-thiones and their 31P and 13C n.m.r. spectral parameters is briefly discussed.
- Mikolajczyk, Marian,Witczak, Malgorzata
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p. 2213 - 2222
(2007/10/07)
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