Natural phosphate and potassium fluoride doped natural phosphate as new catalysts for the Vilsmeir-Haack type reaction
The catalytic activity of the inexpensive natural- or potassium fluoride doped phosphates as bases was evaluated in a Vilsmeier-Haack type reaction. High efficiency, in term of chemical yields and reaction rates was found in the preparation of 2-chlor-3-c
Zahouily, Mohamed,Bahlaouan, Bouchaib,Abrouki, Younes,Salah, Mohamed,Bahlaouan, Ouafa,Rayadh, Ahmed,Aadil, Mina,Sebti, Said
p. 34 - 36
(2007/10/03)
New synthetic routes to 3-, 5-, and 6-aryl-2-chloropyridines
The efficient synthesis of 3-, 5-, and 6-aryl-2-chloropyridines via the facile preparation of 5-(dimethylamino)aryl-substituted pentadienyl nitriles and cyclization with hydrochloric acid is described. This approach allows for the introduction of other electron-withdrawing substituents on the pyridine ring as well as the preparation of the desired unsubstituted arylpyridines. Some differences in the rates of cyclization of the pentadienyl nitriles as well as the yields of chloropyridines were observed that depended on the position and degree of substitution in the aryl substituent. The arylpentadienyl nitriles 5 and 6 could also be converted directly into the corresponding 2-aminopyridines.
Church,Trust,Albright,Powell
p. 3750 - 3758
(2007/10/02)
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