- Structures of (S)-(-)-4-oxo-2-azetidinecarboxylic acid and 3-azetidinecarboxylic acid from powder synchrotron diffraction data
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The crystal structures of the four-membered heterocycles (S)-(-)-4-oxo-2-azetidinecarboxylic acid (I) and 3-azetidinecar-boxylic acid (II) were solved by direct methods using powder synchrotron X-ray diffraction data. The asymmetry of the oxoazetidine and azetidine rings is discussed, along with the hydrogen bonding.
- Mora, Asiloe J.,Brunelli, Michela,Fitch, Andrew N.,Wright, Jonathan,Baez, Maria E.,Lopez-Carrasquero, Francisco
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- Syntheses of hydroxamic acid-containing bicyclic β-lactams via palladium-catalyzed oxidative amidation of alkenes
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Palladium-catalyzed oxidative amidation has been used to synthesize hydroxamic acid-containing bicyclic β-lactam cores. Oxidative cleavage of the pendant alkene provides access to the carboxylic acid in one step.
- Jobbins, Maria O.,Miller, Marvin J.
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p. 1620 - 1625
(2014/03/21)
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- Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
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The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activity, the compounds can be used to enhance memory and to treat a variety of neurological disorders. The compounds are particularly useful for treating neurological disorders caused by, or associated with, CNS trauma.
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Page/Page column 45
(2010/11/26)
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- Carbon based nucleophilic ring opening of activated monocyclic β-lactams; synthesis and stereochemical assignment of the ACE inhibitor WF-10129
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The preparation of γ-keto α-amino acids via carbon based nucleophilic ring opening of activated monocyclic β-lactams was examined and applied to the synthesis and stereochemical assignment of the dipeptide angiotensin convering enzyme (ACE) inhibitor, WF-
- Baldwin, Jack E.,Adlington, Robert M.,Russell, Andrew T.,Smith, Marie L.
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p. 4733 - 4762
(2007/10/02)
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- A NEW SYNTHESIS OF OPTICALLY ACTIVE 2-METHOXYCARBONYL-4-AZETIDINONE FROM L-AZETIDINE-2-CARBOXYLIC ACID: UTILITY OF RUTHENIUM TETROXIDE OXIDATION
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A first transformation of L-azetidine-2-carboxylic acid (1) into optically active monocyclic N-unsubstituted β-lactam, (2S)-2-methoxycarbonyl-4-azetidinone (6), has been developed via ruthenium tetroxide (RuO4) oxidation process.
- Tanaka, Ken-ichi,Yoshifuji, Shigeyuki,Nitta, Yoshihiro
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p. 2539 - 2543
(2007/10/02)
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