N-acylamino acid amide compounds and intermediates for preparation thereof
The present invention discloses the compound represented by the formula (I): wherein A represents the following formula (a-1) or the following formula (a-2): B represents the following formula (b): (wherein the symbols are each as defined in the specification) or a pharmaceutically acceptable salts thereof, and intermediates for the preparation thereof, which have excellent platelet aggregation inhibitory activity and other properties and useful as prophylactic or therapeutic agents for diseases associated with a fibrinogen receptor, thrombosis, infarction and the like.
-
(2008/06/13)
Fused bicyclic Gly-Asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere
6-[4-Amidinobenzoyl]amino]-tetralone-2-acetic acid is a potent antagonist of GPIIb-IIIa. Substitution in the meta position of the benzamidine, or replacement with a heteroaryl amidine was tolerated in this series. Use of an acyl-linked 4-alkyl piperidine
Fisher, Matthew J.,Giese, Ulrich,Harms, Cathy S.,Kinnick, Michael D.,Lindstrom, Terry D.,McCowan, Jefferson R.,Mest, Hans-Juergen,Morin Jr., John M.,Mullaney, Jeffrey T.,Paal, Michael,Rapp, Achim,Ruehter, Gerd,Ruterbories, Ken J.,Sall, Daniel J.,Scarborough, Robert M.,Schotten, Theo,Stenzel, Wolfgang,Towner, Richard D.,Um, Suzane L.,Utterback, Barbara G.,Wyss, Virginia L.,Jakubowski, Joseph A.
p. 385 - 389
(2007/10/03)
More Articles about upstream products of 164149-28-4