- FERROPORTIN INHIBITORS AND METHODS OF USE
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The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.
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Paragraph 0698; 0699
(2020/07/07)
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- THERAPEUTIC COMPOUNDS AND USES THEREOF
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The present invention relates to compounds formula (I): and to salts thereof, wherein R1-R4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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Paragraph 0377; 0378
(2015/03/16)
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- INHIBITORS OF AKT ACTIVITY
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The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on.
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Page/Page column 65
(2010/11/08)
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- Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines
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We report herein the SAR studies of a series of indole-imidazole compounds. that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have
- James, David A.,Koya, Keizo,Li, Hao,Chen, Shoujun,Xia, Zhiqiang,Ying, Weiwen,Wu, Yaming,Sun, Lijun
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p. 5164 - 5168
(2007/10/03)
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- 4-RING IMIDAZOLE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5
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Imidazole compounds of Formula (I): (where A, B, R11, R12, W, X. Y and Z are as defined herein) wherein the imidazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl a
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- DPP IV inhibitors
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The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
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- Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
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The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
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- A convenient set of bidentate pyridine ligands for combinatorial synthesis
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Synthesis is reported of five pyridine-containing bidentate ligands bearing nucleophilic groups at different positions. Their efficient solid- phase alkylation was demonstrated in the synthesis of a small library. These ligands are attractive building blocks for the construction of libraries of metal-binding compounds for various purposes.
- Wang, Fen,Schwabacher, Alan W.
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p. 4779 - 4782
(2007/10/03)
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- A SYNTHESIS OF 2- AND 4(5)-(2-PYRIDINYL)IMIDAZOLES BY PALLADIUM-CATALYSED CROSS-COUPLING REACTIONS
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N-Substituted imidazolylzinc chlorides were reacted with 2-bromopyridine in the presence of Pd(PPh3)4 and a two-fold excess of ZnCl2 to afford cross-coupled products in 58-93percent yields.Deprotection provided convenient routes to 2- or 4(5)-(2-pyridinyl)imidazoles.
- Bell, A. S.,Roberts, D. A.,Ruddock, K. S.
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p. 5013 - 5016
(2007/10/02)
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